Neurotransplantation: Lux et veritas, fiction or reality?

C. Pendleton, I. Ahmed, A. Quinones-Hinojosa

Research output: Contribution to journalReview article

Abstract

Neurotransplantation remains a much-debated fronder in contemporary neurosurgery and neuroscience, with roots dating to the late 19th century. Contemporary applications are far-reaching, and ongoing laboratory research and clinical trials seek to define the mechanisms at play in neurotransplant engraftment and growth, while advancing the field forward into the 21 st century. Neural transplantation therapy remains an attractive idea for treating central nervous system (CNS) and peripheral nervous system (PNS) pathologies. Phase I and phase II clinical trials assessing safety and efficacy are currently underway for various disorders. The remainder of this review will focus on ongoing clinical trials and more recent research advances involving neural transplantation therapy for neuronal death, axonal injury, peripheral nerve lesions, and cancer. The field of neural transplantation, while promising, is not without ethical and scientific dilemmas; this review will conclude with a discussion of the challenges researchers and clinicians face as the field of neural transplantation moves forward.

Original languageEnglish (US)
Pages (from-to)297-304
Number of pages8
JournalJournal of Neurosurgical Sciences
Volume55
Issue number4
StatePublished - Dec 1 2011

Keywords

  • Movement disorders
  • Spinal diseases
  • Stroke
  • Transplantation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Pendleton, C., Ahmed, I., & Quinones-Hinojosa, A. (2011). Neurotransplantation: Lux et veritas, fiction or reality? Journal of Neurosurgical Sciences, 55(4), 297-304.