Abstract
Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, γ-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat.
Original language | English (US) |
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Pages (from-to) | 285-291 |
Number of pages | 7 |
Journal | Developmental Brain Research |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Jul 1982 |
Externally published | Yes |
Keywords
- ferret
- lissencephalic cortex
- methylazoxymethanol acetate
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology