Neurotransmitter chemistry of lissencephalic cortex induced in ferrets by fetal treatment with methylazoxymethanol acetate

M. V. Johnston, R. Haddad, A. Carman-Young, J. T. Coyle

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of pregnant ferrets with 15 mg/kg of methylazoxymethanol acetate (MAM) at 33 days of fetal gestation results in offspring with cortical hypoplasia and lissencephally. Neurochemical analysis of 5 areas of cortex from 8-week-old offspring of MAM- or vehicle-treated jills indicated an overall enrichment in markers for catecholaminergic (tyrosine hydroxylase, norepinephrine) and cholinergic (choline acetyltransferase, acetylcholine) terminals but minimal change in the concentration of GABAergic markers (glutamate decarboxylase, γ-aminobutyric acid); however, there did not appear to be a direct, inverse relationship between the concentration of catecholaminergic and cholinergic markers and the degree of hypoplasia in cortical subareas unlike what has been found previously in the rat.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalDevelopmental Brain Research
Volume4
Issue number3
DOIs
StatePublished - Jul 1982
Externally publishedYes

Keywords

  • ferret
  • lissencephalic cortex
  • methylazoxymethanol acetate

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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