Neurotransmitter alterations in a model of perinatal hypoxic‐ischemic brain injury

Research output: Contribution to journalArticlepeer-review

Abstract

Vulnerability of neurotransmitter‐specific neurons to hypoxia‐ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 hours of 8% oxygen atmosphere at 1 week of age produced ipsilateral striatal injury and reduced hemisphere mass 2 and 6 weeks later. Striatal injury was always more severe than damage to overlying cortex. Over half the animals had status marmoratus, a neuropathological change seen in the basal ganglia and thalamus after hypoxic‐ischemic injury in full‐term human infants. Two weeks after the insult, markers for choinergic, dopaminergic, and γ‐aminobutyric acid–containing neurons were all reduced, but the reduction in cholinergic markers was greater than that for the other two transmitters. Muscarinic cholinergic receptors were relatively preserved, but their distribution was disrupted. In adult animals specific activity of cholinergic neuronal markers was normal, suggesting that the balance of neurotransmitters was restored after the early insult.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalAnnals of neurology
Volume13
Issue number5
DOIs
StatePublished - May 1983
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Neurotransmitter alterations in a model of perinatal hypoxic‐ischemic brain injury'. Together they form a unique fingerprint.

Cite this