TY - JOUR
T1 - Neurotransmitter alterations in a model of perinatal hypoxic‐ischemic brain injury
AU - Johnston, Michael V.
PY - 1983/5
Y1 - 1983/5
N2 - Vulnerability of neurotransmitter‐specific neurons to hypoxia‐ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 hours of 8% oxygen atmosphere at 1 week of age produced ipsilateral striatal injury and reduced hemisphere mass 2 and 6 weeks later. Striatal injury was always more severe than damage to overlying cortex. Over half the animals had status marmoratus, a neuropathological change seen in the basal ganglia and thalamus after hypoxic‐ischemic injury in full‐term human infants. Two weeks after the insult, markers for choinergic, dopaminergic, and γ‐aminobutyric acid–containing neurons were all reduced, but the reduction in cholinergic markers was greater than that for the other two transmitters. Muscarinic cholinergic receptors were relatively preserved, but their distribution was disrupted. In adult animals specific activity of cholinergic neuronal markers was normal, suggesting that the balance of neurotransmitters was restored after the early insult.
AB - Vulnerability of neurotransmitter‐specific neurons to hypoxia‐ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 hours of 8% oxygen atmosphere at 1 week of age produced ipsilateral striatal injury and reduced hemisphere mass 2 and 6 weeks later. Striatal injury was always more severe than damage to overlying cortex. Over half the animals had status marmoratus, a neuropathological change seen in the basal ganglia and thalamus after hypoxic‐ischemic injury in full‐term human infants. Two weeks after the insult, markers for choinergic, dopaminergic, and γ‐aminobutyric acid–containing neurons were all reduced, but the reduction in cholinergic markers was greater than that for the other two transmitters. Muscarinic cholinergic receptors were relatively preserved, but their distribution was disrupted. In adult animals specific activity of cholinergic neuronal markers was normal, suggesting that the balance of neurotransmitters was restored after the early insult.
UR - http://www.scopus.com/inward/record.url?scp=0020539085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020539085&partnerID=8YFLogxK
U2 - 10.1002/ana.410130507
DO - 10.1002/ana.410130507
M3 - Article
C2 - 6135388
AN - SCOPUS:0020539085
SN - 0364-5134
VL - 13
SP - 511
EP - 518
JO - Annals of neurology
JF - Annals of neurology
IS - 5
ER -