Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury

Research output: Contribution to journalArticle

Abstract

Vulnerability of neutrotransmitter-specific neurons to hypoxia-ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 hours of 8% oxygen atmosphere at 1 week of age produced ipsilateral striatal injury and reduced hemisphere mass 2 and 6 weeks later. Striatal injury was always more severe than damage to overlying cortex. Over half the animals had status marmoratus, a neuropathological change seen in the basal ganglia and thalamus after hypoxic-ischemic injury in full-term human infants. Two weeks after the insult, markers for cholinergic, dopaminergic, and γ-aminobutyric acid-containing neurons were all reduced, but the reduction in cholinergic markers was greater than that for the other two transmitters. Muscarinic cholinergic reeceptors were relatively preserved, but their distribution was disrupted. In adult animals specific activity of cholinergic neuronal markers was normal, suggesting that the balance of neurotransmitters was restored after the early insult.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalAnnals of Neurology
Volume13
Issue number5
StatePublished - 1983
Externally publishedYes

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Brain Injuries
Cholinergic Agents
Neurotransmitter Agents
Corpus Striatum
Wounds and Injuries
Aminobutyrates
Neurons
Movement Disorders
Basal Ganglia
Thalamus
Atmosphere
Carotid Arteries
Ligation
Ischemia
Oxygen

ASJC Scopus subject areas

  • Neuroscience(all)

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Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury. / Johnston, Michael V.

In: Annals of Neurology, Vol. 13, No. 5, 1983, p. 511-518.

Research output: Contribution to journalArticle

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