Neurotoxicity of misonidazole in rats. I. Neuropathology

J. W. Griffin, D. L. Price, D. O. Kuethe, Alan Goldberg

Research output: Contribution to journalArticle

Abstract

Misonidazole is a 2-nitroimidazole compound developed as a hypoxic cell sensitizer for cancer radiotherapy. Because neurotoxicity has occurred in clinical trials, we have examined the neuropathology of intoxicated rats. In the peripheral nervous system, changes consisted of distal axonal degeneration in intramuscular nerve branches, and edema in dorsal root ganglia. In the central nervous system, spongy changes were found in the lateral and superior vestibular nuclei, the superior olives, and often in the cochlear nuclei and cerebellar roof nuclei. In advanced lesions these structures underwent necrosis and scattered petechiae were found around the IVth ventricle. The pathology resembled that associated with thiamine deficiency in the rat.

Original languageEnglish (US)
Pages (from-to)299-312
Number of pages14
JournalNeuroToxicology
Volume1
Issue number2
StatePublished - 1979

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Misonidazole
Neurology
Rats
Lateral Vestibular Nucleus
Thiamine Deficiency
Cochlear Nucleus
Cerebellar Nuclei
Purpura
Thiamine
Peripheral Nervous System
Radiotherapy
Spinal Ganglia
Pathology
Roofs
Edema
Necrosis
Central Nervous System
Cells
Clinical Trials
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Griffin, J. W., Price, D. L., Kuethe, D. O., & Goldberg, A. (1979). Neurotoxicity of misonidazole in rats. I. Neuropathology. NeuroToxicology, 1(2), 299-312.

Neurotoxicity of misonidazole in rats. I. Neuropathology. / Griffin, J. W.; Price, D. L.; Kuethe, D. O.; Goldberg, Alan.

In: NeuroToxicology, Vol. 1, No. 2, 1979, p. 299-312.

Research output: Contribution to journalArticle

Griffin, JW, Price, DL, Kuethe, DO & Goldberg, A 1979, 'Neurotoxicity of misonidazole in rats. I. Neuropathology', NeuroToxicology, vol. 1, no. 2, pp. 299-312.
Griffin, J. W. ; Price, D. L. ; Kuethe, D. O. ; Goldberg, Alan. / Neurotoxicity of misonidazole in rats. I. Neuropathology. In: NeuroToxicology. 1979 ; Vol. 1, No. 2. pp. 299-312.
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