Neurotoxicity of misonidazole in rats. I. Neuropathology

J. W. Griffin, D. L. Price, D. O. Kuethe, A. M. Goldberg

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Misonidazole is a 2-nitroimidazole compound developed as a hypoxic cell sensitizer for cancer radiotherapy. Because neurotoxicity has occurred in clinical trials, we have examined the neuropathology of intoxicated rats. In the peripheral nervous system, changes consisted of distal axonal degeneration in intramuscular nerve branches, and edema in dorsal root ganglia. In the central nervous system, spongy changes were found in the lateral and superior vestibular nuclei, the superior olives, and often in the cochlear nuclei and cerebellar roof nuclei. In advanced lesions these structures underwent necrosis and scattered petechiae were found around the IVth ventricle. The pathology resembled that associated with thiamine deficiency in the rat.

Original languageEnglish (US)
Pages (from-to)299-312
Number of pages14
Issue number2
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology


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