Neurotoxicity of misonidazole in rats. I. Neuropathology

J. W. Griffin, D. L. Price, D. O. Kuethe, A. M. Goldberg

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Misonidazole is a 2-nitroimidazole compound developed as a hypoxic cell sensitizer for cancer radiotherapy. Because neurotoxicity has occurred in clinical trials, the authors examined the neuropathology of intoxicated rats. In the peripheral nervous system, changes consisted of distal axonal degeneration in intramuscular nerve branches, and edema in dorsal root ganglia. In the central nervous system, spongy changes were found in the lateral and superior vestibular nuclei, the superior olives, and often in the cochlear nuclei and cerebellar roof nuclei. In advanced lesions, these structures underwent necrosis and scattered petechiae were found around the IVth ventricle. The pathology resembled that associated with thiamine deficiency in the rat.

Original languageEnglish (US)
Pages (from-to)653-666
Number of pages14
JournalNeuroToxicology
Volume1
Issue number3
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General Neuroscience
  • Toxicology

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