Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia

Avindra Nath, Carol Anderson, Melina Jones, William Maragos, Rosemarie Booze, Charles Mactutus, Jeanne Bell, Kurt Hauser, Mark Mattson

Research output: Contribution to journalArticle

Abstract

Infection with the human immunodefiency virus (HIV) selectively targets the basal ganglia resulting in loss of dopaminergic neurons. Although frequently asymptomatic, some patients may develop signs of dopamine deficiency de novo. Accordingly, they are highly susceptible to drugs that act on dopaminergic systems. Both neuroleptics and psychostimulants may exacerbate these symptoms. Experimental evidence suggests that viral proteins such as gp120 and Tat can cause toxicity to dopaminergic neurons, and this toxicity is synergistic with compounds such as methamphetamine and cocaine that also act on the dopaminergic system. In addition, other neurotransmitters that modulate dopaminergic function, such as glutamate and opioids, may also modify the susceptibility of the dopamine system to HIV. Therefore, a thorough understanding of the mechanisms that lead to this selective neurotoxicity of dopaminergic neurons would also likely lead to the development of therapeutic modalities for patients with HIV dementia.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalJournal of Psychopharmacology
Volume14
Issue number3
Publication statusPublished - 2000
Externally publishedYes

    Fingerprint

Keywords

  • AIDS
  • Basa ganglia
  • Brain
  • Cocaine
  • Dementia
  • Dopamine
  • HIV
  • Methamphetamine
  • Neuroleptics
  • Opia tes
  • Parkinson's disease

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Nath, A., Anderson, C., Jones, M., Maragos, W., Booze, R., Mactutus, C., ... Mattson, M. (2000). Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. Journal of Psychopharmacology, 14(3), 222-227.