TY - JOUR
T1 - Neurotoxic hippocampal lesions fail to impair reinstatement of an appetitively conditioned response
AU - Fox, Gregory D.
AU - Holland, Peter C.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - Rats with ibotenate lesions of the hippocampus (HPC) and nonlesioned rats were trained with a Pavlovian appetitive conditioning procedure in which a visual conditioned stimulus (CS) was first paired with a food unconditioned stimulus (US) and then repeatedly presented in the absence of the food US. After extinction of the conditioned response (CR), half of the rats received presentations of the food US and half did not. On a final test of responding to the visual CS, rats that received the postextinction US presentations showed higher levels of conditioned responding than the rats that did not. This reinstatement of CRs was not affected by the HPC lesions, which nevertheless impaired performance on a water maze task known to be sensitive to HPC damage. These data are in contrast to those of A. Wilson, D.C. Brooks, and M. E. Bouton (1995), who found that lesions of the fornix abolished reinstatement of aversively conditioned behavior.
AB - Rats with ibotenate lesions of the hippocampus (HPC) and nonlesioned rats were trained with a Pavlovian appetitive conditioning procedure in which a visual conditioned stimulus (CS) was first paired with a food unconditioned stimulus (US) and then repeatedly presented in the absence of the food US. After extinction of the conditioned response (CR), half of the rats received presentations of the food US and half did not. On a final test of responding to the visual CS, rats that received the postextinction US presentations showed higher levels of conditioned responding than the rats that did not. This reinstatement of CRs was not affected by the HPC lesions, which nevertheless impaired performance on a water maze task known to be sensitive to HPC damage. These data are in contrast to those of A. Wilson, D.C. Brooks, and M. E. Bouton (1995), who found that lesions of the fornix abolished reinstatement of aversively conditioned behavior.
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U2 - 10.1037/0735-7044.112.1.255
DO - 10.1037/0735-7044.112.1.255
M3 - Article
C2 - 9517833
AN - SCOPUS:0031906956
SN - 0735-7044
VL - 112
SP - 255
EP - 260
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 1
ER -