Neurotoxic effects of methamphetamine

Bessy Thrash, Senthilkumar S. Karuppagounder, Subramaniam Uthayathas, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran

Research output: Contribution to journalArticlepeer-review


In Parkinson's disease, depletion of dopamine in the striatum leads to various symptoms such as tremor, rigidity and akinesia. Methamphetamine use has significantly increased in USA and around the world and there are several reports showing that its long-term use increases the risk for dopamine depletion. However, the toxic mechanisms of methamphetamine are not well understood. This study was undertaken to gain greater mechanistic understanding of the toxicity induced by methamphetamine. We evaluated the effect of methamphetamine on the generation of reactive oxygen species, mitochondrial monoamine oxidase, complex I & IV activities. Behavioral analysis evaluated the effect on catalepsy, akinesia and swim score. Neurotransmitter levels were evaluated using high pressure liquid chromatography (HPLC) electrochemical detection (ECD). Results showed that methamphetamine caused significant generation of reactive oxygen species and decreased complex I activity in the mitochondria leading to dopamine depletion in the striatum.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalNeurochemical Research
Issue number1
StatePublished - Jan 2010
Externally publishedYes


  • Behavior
  • Dopamine
  • Methamphetamine
  • Neurotoxicity
  • Oxidative stress
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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