Neurosyphilis

Knowledge Gaps and Controversies

Research output: Contribution to journalReview article

Abstract

After reaching a nadir at the turn of the century, syphilis rates in the United States have increased since 2000. Treponema pallidum may disseminate to the central nervous system within hours to days after inoculation. In this review, we focus on knowledge gaps and areas of controversy in neurosyphilis epidemiology, diagnosis, and management. Modern estimates of the prevalence of neurosyphilis are hindered by the lack of consistent reporting data and are based on relatively small retrospective cohort studies. The various diagnostic modalities for neurosyphilis have significant limitations. Although several novel biomarkers for neurosyphilis have been evaluated, none to date have found a place in clinical practice. The role of a cerebrospinal fluid examination in patients without neurological symptoms continues to be an area of controversy, whereas the data for the use of antibiotic regimens other than intravenous aqueous or intramuscular procaine penicillin for the treatment of neurosyphilis are limited. As syphilis incidence continues to increase unabated in many countries around the world, it is critical to address these gaps of knowledge.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalSexually Transmitted Diseases
Volume45
Issue number3
DOIs
StatePublished - Mar 1 2018
Externally publishedYes

Fingerprint

Neurosyphilis
Syphilis
Penicillin G Procaine
Treponema pallidum
Cerebrospinal Fluid
Epidemiology
Cohort Studies
Research Design
Central Nervous System
Retrospective Studies
Biomarkers
Anti-Bacterial Agents
Incidence

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Neurosyphilis : Knowledge Gaps and Controversies. / Tuddenham, Susan; Ghanem, Khalil G.

In: Sexually Transmitted Diseases, Vol. 45, No. 3, 01.03.2018, p. 147-151.

Research output: Contribution to journalReview article

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