Neurosurgical treatment of cancer pain

Robert W. Hurley, Frederick Lenz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Over the past 30 years, there have been significant changes in neurosurgical approaches to the treatment of cancer pain. Specifically, there has been a substantial decrease in the number of ablative procedures and an increase in the number of interventional pain and implantation procedures for treatment of chronic pain. The application of ablative surgery has been diminished in part because of the increasing recognition that some types of persistent pain are the result of injuries to the nervous system. In the treatment of pain of malignant origin in patients with a life expectancy of less than 3 months, this is often less of a concern, as the pain relief provided by the procedure is often good for the patient's remaining life. The indications for all pain treatment, particularly neurosurgical treatments, are dependent on the type of pain. Nociceptive pain refers to pain arising from the activation of peripheral nociceptors and transmitted to the central nervous system through intact somatic sensory pathways. Examples of nociceptive pain include acute cancer pain secondary to invasion of bone. This pain has been said to respond well to opiates. Neuropathic pain refers to pain arising from injury to the nervous system either peripherally, such as malignant invasion of pancreatic cancer into the celiac plexus or diabetic peripheral neuropathy, or centrally, such as post-stroke pain. It has been suggested that central pain does not respond to opiates, although this is certainly not universally accepted.

Original languageEnglish (US)
Title of host publicationCancer Pain: Assessment and Management, Second Edition
PublisherCambridge University Press
Pages329-340
Number of pages12
ISBN (Print)9780511642357, 9780521879279
DOIs
Publication statusPublished - Jan 1 2009

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hurley, R. W., & Lenz, F. (2009). Neurosurgical treatment of cancer pain. In Cancer Pain: Assessment and Management, Second Edition (pp. 329-340). Cambridge University Press. https://doi.org/10.1017/CBO9780511642357.018