Neurosurgical tools to extend tumor resection in hemispheric low-grade gliomas: conventional and contrast enhanced ultrasonography

Luca Mattei, Francesco Prada, Federico Giuseppe Legnani, Alessandro Perin, Alessandro Olivi, Francesco DiMeco

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Purpose: Pediatric low-grade gliomas (LGGs) are the most frequent solid tumor in childhood. Based on an increasing number of literature reports, maximal safe resection is recommended as the first line of treatment whenever possible. However, distinguishing tumor tissue from the surrounding normal brain is often challenging with infiltrating neoplasms, even with the assistance of intraoperative, microscopic and conventional neuronavigation systems. Therefore, any technique that enhances the detection and visualization of LGGs intraoperatively is certainly desirable. Methods: In this paper, we reviewed the role of intraoperative conventional ultrasound and contrast-enhanced ultrasound (CEUS) as a tool for extending tumor resection in LGGs. Moreover, our experience with this technology is reported and discussed. Results: Both B-mode and CEUS are helpful in highlighting LGGs, detecting tumor margins and providing additional information such as vascularization, thus improving the safety of a more radical resection. Conclusions: Although the full potentialities of the method are yet to be explored, intraoperative ultrasound is a promising tool in oncologic surgery and LGG surgery.

Original languageEnglish (US)
Pages (from-to)1907-1914
Number of pages8
JournalChild's Nervous System
Issue number10
StatePublished - Oct 1 2016


  • CEUS
  • Low-grade glioma
  • Pediatric brain tumor
  • Ultrasound
  • Ultrasound contrast-agent

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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