Neurosurgical intervention in the diagnosis and treatment of Balamuthia mandrillaris encephalitis: Report of 3 cases

Ludwig Orozco, William Hanigan, Majid Khan, Jonathan Fratkin, Marcus Lee

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe the unique presentation of Balamuthia mandrillaris encephalitis in a kidney donor and two recipients. All three patients suffered acute clinical deterioration, with radiological or clinical evidence of intracranial hypertension. Brain autopsy in the donor and an urgent brain biopsy in a recipient established the diagnosis. First-tier therapy, with mannitol and CSF drainage, successfully treated the intracranial hypertension in both recipients, while administration of a combination of antiamebic drugs was associated with survival in the second recipient. For both recipients, neurosurgical management played a critical role in the rapid diagnosis and treatment of Balamuthia mandrillaris encephalitis.

Original languageEnglish (US)
Pages (from-to)636-640
Number of pages5
JournalJournal of neurosurgery
Volume115
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Balamuthia mandrillaris encephalitis
  • Infection
  • Intracranial hypertension

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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