TY - JOUR
T1 - Neurosurgical intervention in the diagnosis and treatment of Balamuthia mandrillaris encephalitis
T2 - Report of 3 cases
AU - Orozco, Ludwig
AU - Hanigan, William
AU - Khan, Majid
AU - Fratkin, Jonathan
AU - Lee, Marcus
PY - 2011/9
Y1 - 2011/9
N2 - The authors describe the unique presentation of Balamuthia mandrillaris encephalitis in a kidney donor and two recipients. All three patients suffered acute clinical deterioration, with radiological or clinical evidence of intracranial hypertension. Brain autopsy in the donor and an urgent brain biopsy in a recipient established the diagnosis. First-tier therapy, with mannitol and CSF drainage, successfully treated the intracranial hypertension in both recipients, while administration of a combination of antiamebic drugs was associated with survival in the second recipient. For both recipients, neurosurgical management played a critical role in the rapid diagnosis and treatment of Balamuthia mandrillaris encephalitis.
AB - The authors describe the unique presentation of Balamuthia mandrillaris encephalitis in a kidney donor and two recipients. All three patients suffered acute clinical deterioration, with radiological or clinical evidence of intracranial hypertension. Brain autopsy in the donor and an urgent brain biopsy in a recipient established the diagnosis. First-tier therapy, with mannitol and CSF drainage, successfully treated the intracranial hypertension in both recipients, while administration of a combination of antiamebic drugs was associated with survival in the second recipient. For both recipients, neurosurgical management played a critical role in the rapid diagnosis and treatment of Balamuthia mandrillaris encephalitis.
KW - Balamuthia mandrillaris encephalitis
KW - Infection
KW - Intracranial hypertension
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U2 - 10.3171/2011.4.JNS102057
DO - 10.3171/2011.4.JNS102057
M3 - Article
C2 - 21619411
AN - SCOPUS:80052346773
VL - 115
SP - 636
EP - 640
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 3
ER -