Neurosurgical Implant-Based Strategy for Brain Cancer Therapy

Joshua Casaos, Noah Gorelick, Betty Tyler

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Glioblastoma has long proven to be a challenging disease in regard to chemotherapeutic delivery as it grows within a privileged site protected by the selective blood-brain barrier. For many years biodegradable polymers were investigated as potential drug delivery systems. However, polymer technology in the drug delivery setting only truly advanced after the polyanhydrides were tested and demonstrated to be safe and effective platforms for controlled delivery of hydrolytically unstable chemotherapeutics. An in-depth series of biochemical and preclinical studies laid the foundation for the translation of these findings into clinical use for the treatment of glioblastoma with carmustine. This chapter provides the historical perspective of the carmustine implants through preclinical safety, intracranial distribution, and efficacy studies to clinical trials in recurrent and newly diagnosed glioblastoma and subsequent FDA approval of this chemotherapeutic delivery concept. Moreover, these studies provide a successful framework on which to expand in this new era of targeted and controlled drug delivery.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages225-244
Number of pages20
DOIs
StatePublished - 2021

Publication series

NameNeuromethods
Volume163
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • BCNU wafers
  • Blood-brain barrier
  • Chemotherapy
  • Local drug delivery
  • Polyanhydrides

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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