Abstract
Child maltreatment has been associated with different psychiatric disorders. Studies on both animals and humans have suggested that some brain areas would be directly affected by severe psychological trauma. The pathophsysiology of post-traumatic stress disorder (PTSD) appears to be related to a complex interaction involving genetic and environmental factors. Advanced neuroimaging techniques have been used to investigate neurofunctional and neurostructural abnormalities in children, adolescents, and adults with PTSD. This review examined structural brain imaging studies that were performed in abused and traumatized children, and discusses the possible biological mechanisms involved in the pathophysiology of PTSD, the implications and future directions for magnetic resonance imaging (MRI) studies. Published reports in refereed journals were reviewed by searching Medline and examining references of the articles related to structural neuroimaging of PTSD. Structural MRI studies have been performed in adults and children to evaluate the volumetric brain alterations in the PTSD population. In contrast with studies involving adults, in which hippocampus volumetric reduction was the most consistent finding, studies involving children and adolescents with PTSD have demonstrated smaller medial and posterior portions of the corpus callosum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Psychiatry and Clinical Neurosciences |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2009 |
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Keywords
- Child maltreatment
- Corpus callosum
- Hippocampus
- Magnetic resonance imaging
- Post-traumatic stress disorder
ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Neurostructural imaging findings in children with post-traumatic stress disorder : Brief review. / Jackowski, Andrea Parolin; De Araújo, Celia Maria; De Lacerda, Acioly Luiz Tavares; De Jesus Mari, Jair; Kaufman, Joan.
In: Psychiatry and Clinical Neurosciences, Vol. 63, No. 1, 02.2009, p. 1-8.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Neurostructural imaging findings in children with post-traumatic stress disorder
T2 - Brief review
AU - Jackowski, Andrea Parolin
AU - De Araújo, Celia Maria
AU - De Lacerda, Acioly Luiz Tavares
AU - De Jesus Mari, Jair
AU - Kaufman, Joan
PY - 2009/2
Y1 - 2009/2
N2 - Child maltreatment has been associated with different psychiatric disorders. Studies on both animals and humans have suggested that some brain areas would be directly affected by severe psychological trauma. The pathophsysiology of post-traumatic stress disorder (PTSD) appears to be related to a complex interaction involving genetic and environmental factors. Advanced neuroimaging techniques have been used to investigate neurofunctional and neurostructural abnormalities in children, adolescents, and adults with PTSD. This review examined structural brain imaging studies that were performed in abused and traumatized children, and discusses the possible biological mechanisms involved in the pathophysiology of PTSD, the implications and future directions for magnetic resonance imaging (MRI) studies. Published reports in refereed journals were reviewed by searching Medline and examining references of the articles related to structural neuroimaging of PTSD. Structural MRI studies have been performed in adults and children to evaluate the volumetric brain alterations in the PTSD population. In contrast with studies involving adults, in which hippocampus volumetric reduction was the most consistent finding, studies involving children and adolescents with PTSD have demonstrated smaller medial and posterior portions of the corpus callosum.
AB - Child maltreatment has been associated with different psychiatric disorders. Studies on both animals and humans have suggested that some brain areas would be directly affected by severe psychological trauma. The pathophsysiology of post-traumatic stress disorder (PTSD) appears to be related to a complex interaction involving genetic and environmental factors. Advanced neuroimaging techniques have been used to investigate neurofunctional and neurostructural abnormalities in children, adolescents, and adults with PTSD. This review examined structural brain imaging studies that were performed in abused and traumatized children, and discusses the possible biological mechanisms involved in the pathophysiology of PTSD, the implications and future directions for magnetic resonance imaging (MRI) studies. Published reports in refereed journals were reviewed by searching Medline and examining references of the articles related to structural neuroimaging of PTSD. Structural MRI studies have been performed in adults and children to evaluate the volumetric brain alterations in the PTSD population. In contrast with studies involving adults, in which hippocampus volumetric reduction was the most consistent finding, studies involving children and adolescents with PTSD have demonstrated smaller medial and posterior portions of the corpus callosum.
KW - Child maltreatment
KW - Corpus callosum
KW - Hippocampus
KW - Magnetic resonance imaging
KW - Post-traumatic stress disorder
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U2 - 10.1111/j.1440-1819.2008.01906.x
DO - 10.1111/j.1440-1819.2008.01906.x
M3 - Review article
C2 - 19154207
AN - SCOPUS:58449123046
VL - 63
SP - 1
EP - 8
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
IS - 1
ER -