Abstract
Sarcoidosis is a multisystemic inflammatory granulomatous disease that affects both the central and peripheral nervous system. The neurological manifestations depend on the areas of the neuroaxis affected. In the brain, patients with neurosarcoidosis have leptomeningeal and intraparenchymal infiltration of granulomas that leads to, for example, cranial nerve palsies, basal meningitis, and endocrine dysfunction. It can cause peripheral neuropathies such as mononeuritis multiplex and sensorimotor polyneuropathy as well as radiculopathy and myopathy. Diagnosis and management of patients with neurosarcoidosis are challenging given that the gold standard is tissue-proven biopsy, which, in most cases of neurological illness, is difficult to obtain. Treatment strategies have not been rigorously evaluated but corticosteroids are considered the drug of choice. Other immunosuppressant agents such as cyclophosphamide, mycophenolate mofetil, and infliximab are efficacious in the treatment of neurosarcoidosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 419-427 |
| Number of pages | 9 |
| Journal | Seminars in Respiratory and Critical Care Medicine |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 3 2010 |
| Externally published | Yes |
Fingerprint
Keywords
- immunosuppression
- inflammation
- Neurosarcoidosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
Cite this
Neurosarcoidosis : Diagnosis and management. / Vargas, Diana L.; Stern, Barney.
In: Seminars in Respiratory and Critical Care Medicine, Vol. 31, No. 4, 03.08.2010, p. 419-427.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Neurosarcoidosis
T2 - Diagnosis and management
AU - Vargas, Diana L.
AU - Stern, Barney
PY - 2010/8/3
Y1 - 2010/8/3
N2 - Sarcoidosis is a multisystemic inflammatory granulomatous disease that affects both the central and peripheral nervous system. The neurological manifestations depend on the areas of the neuroaxis affected. In the brain, patients with neurosarcoidosis have leptomeningeal and intraparenchymal infiltration of granulomas that leads to, for example, cranial nerve palsies, basal meningitis, and endocrine dysfunction. It can cause peripheral neuropathies such as mononeuritis multiplex and sensorimotor polyneuropathy as well as radiculopathy and myopathy. Diagnosis and management of patients with neurosarcoidosis are challenging given that the gold standard is tissue-proven biopsy, which, in most cases of neurological illness, is difficult to obtain. Treatment strategies have not been rigorously evaluated but corticosteroids are considered the drug of choice. Other immunosuppressant agents such as cyclophosphamide, mycophenolate mofetil, and infliximab are efficacious in the treatment of neurosarcoidosis.
AB - Sarcoidosis is a multisystemic inflammatory granulomatous disease that affects both the central and peripheral nervous system. The neurological manifestations depend on the areas of the neuroaxis affected. In the brain, patients with neurosarcoidosis have leptomeningeal and intraparenchymal infiltration of granulomas that leads to, for example, cranial nerve palsies, basal meningitis, and endocrine dysfunction. It can cause peripheral neuropathies such as mononeuritis multiplex and sensorimotor polyneuropathy as well as radiculopathy and myopathy. Diagnosis and management of patients with neurosarcoidosis are challenging given that the gold standard is tissue-proven biopsy, which, in most cases of neurological illness, is difficult to obtain. Treatment strategies have not been rigorously evaluated but corticosteroids are considered the drug of choice. Other immunosuppressant agents such as cyclophosphamide, mycophenolate mofetil, and infliximab are efficacious in the treatment of neurosarcoidosis.
KW - immunosuppression
KW - inflammation
KW - Neurosarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=77955036314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955036314&partnerID=8YFLogxK
U2 - 10.1055/s-0030-1262210
DO - 10.1055/s-0030-1262210
M3 - Review article
C2 - 20665392
AN - SCOPUS:77955036314
VL - 31
SP - 419
EP - 427
JO - Seminars in Respiratory and Critical Care Medicine
JF - Seminars in Respiratory and Critical Care Medicine
SN - 1069-3424
IS - 4
ER -