Neurosarcoidosis

Jinny O. Tavee, Barney J. Stern

Research output: Contribution to journalReview articlepeer-review

Abstract

PURPOSE OF REVIEW: This article provides an update on the evaluation and treatment of neurosarcoidosis. RECENT FINDINGS: The broad range of clinical manifestations of neurosarcoidosis has recently expanded to include painful small fiber neuropathy. Although definitive diagnosis remains a challenge, fluorodeoxyglucose positron emission tomographic (FDG-PET) scan and high-resolution CT allow for improved detection of systemic sarcoidosis. In addition, endobronchial ultrasound-guided transbronchial needle aspiration provides a less invasive means of tissue confirmation of systemic sarcoidosis than mediastinoscopy. Although not standardized, treatment strategies for neurosarcoidosis now commonly include tumor necrosis factor-α antagonists in combination with corticosteroids and other cytotoxic agents for patients with severe disease. SUMMARY: Advances in the diagnosis and management of neurosarcoidosis may benefit the patient and clinician faced with this multifaceted disease.

Original languageEnglish (US)
Pages (from-to)545-559
Number of pages15
JournalCONTINUUM Lifelong Learning in Neurology
Volume20
Issue number3
DOIs
StatePublished - Jun 2014
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

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