TY - GEN
T1 - Neuroregulation of human nasal mucosa
AU - Baraniuk, James N.
AU - Merck, Samantha J.
PY - 2009/7
Y1 - 2009/7
N2 - Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identification of distinct classes of nociceptive nerves with unique patterns of transient receptor potential sensory receptor ion channel proteins may account for the polymodal, chemo- and mechanicosensitivity of many trigeminal neurons. Modulation of these families of proteins, excitatory and inhibitory autoreceptors, and combinations of neurotransmitters introduces a new level of complexity and subtlety to nasal innervation. These findings may provide a rational basis for responses to air-temperature changes, culinary and botanical odorants ("aromatherapy"), and inhaled irritants in conditions as diverse as allergic and nonallergic rhinitis, occupational rhinitis, hyposmia, and multiple chemical sensitivity.
AB - Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identification of distinct classes of nociceptive nerves with unique patterns of transient receptor potential sensory receptor ion channel proteins may account for the polymodal, chemo- and mechanicosensitivity of many trigeminal neurons. Modulation of these families of proteins, excitatory and inhibitory autoreceptors, and combinations of neurotransmitters introduces a new level of complexity and subtlety to nasal innervation. These findings may provide a rational basis for responses to air-temperature changes, culinary and botanical odorants ("aromatherapy"), and inhaled irritants in conditions as diverse as allergic and nonallergic rhinitis, occupational rhinitis, hyposmia, and multiple chemical sensitivity.
KW - Nociception
KW - Nociceptive axon response
KW - TRPV1
KW - Transient receptor potential
UR - http://www.scopus.com/inward/record.url?scp=68649121662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68649121662&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04481.x
DO - 10.1111/j.1749-6632.2009.04481.x
M3 - Conference contribution
C2 - 19686200
AN - SCOPUS:68649121662
SN - 9781573317382
T3 - Annals of the New York Academy of Sciences
SP - 604
EP - 609
BT - International Symposium on Olfaction and Taste
PB - Blackwell Publishing Inc.
ER -