Neuropsychological test performance before and after HIV-1 seroconversion: The Multicenter AIDS Cohort Study

Quynh T. Vo, Christopher Cox, Xiuhong Li, Lisa Paula Jacobson, Rosemary McKaig, Ned Sacktor, Ola A. Selnes, Eileen Martin, James T. Becker, Eric N. Miller

Research output: Contribution to journalArticle

Abstract

The objective of this study is to compare neuropsychological test performance before and after HIV-1 seroconversion in order to identify possible acute changes in psychomotor speed, memory, attention, and concentration secondary to seroconversion. The study utilized mixed effects models to examine longitudinal neuropsychological test data. We conducted a nested cohort study of 362 male HIV-1 seroconverters enrolled in the Multicenter AIDS Cohort Study. We used linear mixed models with random subject effects to compare repeated neuropsychological test outcomes from 5 years before seroconversion to 2 years after seroconversion on the Trail Making Test (parts A and B), Symbol-Digit Test, Grooved Pegboard (dominant and non-dominant hands), Stroop Color-Interference Test, Rey Auditory Verbal Learning Test, and the CalCAP Reaction Time Test. We found no significant changes in the time-dependent score after seroconversion for the majority of neuropsychological tests used in the Multicenter AIDS Cohort Study. There was a significant change in time trend after seroconversion on part B of the Trail Making Test (p = 0.042), but the difference only represented a 2 % decrease in performance. We found the following characteristics to be associated with worse neuropsychological test performance: lower education levels, history of depression, older age, and no previous neurocognitive testing (p

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalJournal of NeuroVirology
Volume19
Issue number1
DOIs
StatePublished - 2013

Fingerprint

HIV Seropositivity
Neuropsychological Tests
HIV-1
Acquired Immunodeficiency Syndrome
Cohort Studies
Trail Making Test
Verbal Learning
Reaction Time
Linear Models
Hand
Color
Seroconversion
Depression
Education

Keywords

  • CD4
  • HIV
  • Neurocognition
  • Neuropsychological test
  • Seroconversion

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Neuropsychological test performance before and after HIV-1 seroconversion : The Multicenter AIDS Cohort Study. / Vo, Quynh T.; Cox, Christopher; Li, Xiuhong; Jacobson, Lisa Paula; McKaig, Rosemary; Sacktor, Ned; Selnes, Ola A.; Martin, Eileen; Becker, James T.; Miller, Eric N.

In: Journal of NeuroVirology, Vol. 19, No. 1, 2013, p. 24-31.

Research output: Contribution to journalArticle

Vo, Quynh T. ; Cox, Christopher ; Li, Xiuhong ; Jacobson, Lisa Paula ; McKaig, Rosemary ; Sacktor, Ned ; Selnes, Ola A. ; Martin, Eileen ; Becker, James T. ; Miller, Eric N. / Neuropsychological test performance before and after HIV-1 seroconversion : The Multicenter AIDS Cohort Study. In: Journal of NeuroVirology. 2013 ; Vol. 19, No. 1. pp. 24-31.
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