Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: effects of 12-month stimulation.

Christiane Grubert, René Hurlemann, Bettina H. Bewernick, Sarah Kayser, Barbara Hadrysiewicz, Nikolai Axmacher, Volker Sturm, Thomas E. Schlaepfer

Research output: Contribution to journalArticle

Abstract

Deep brain stimulation (DBS) to the nucleus accumbens (NAcc-DBS) has antidepressant effects in patients suffering from treatment-resistant depression (TRD). However, limited information exists regarding the impact of NAcc-DBS on cognitive functioning. The aim of this study was to examine whether NAcc-DBS in patients with TRD has any cognitive effects. A comprehensive neuropsychological battery was administered to 10 patients with TRD before onset of bilateral NAcc-DBS and after 1 year of DBS stimulation. Neuropsychological testing covered the domains of attention, learning and memory, executive functions, visual perception, and language. Performance was analyzed at baseline and after 1 year of continuous DBS. No evidence was found for cognitive decline following NAcc-DBS comparing test results after 1 year of NAcc-DBS with baseline. However, significantly improved cognitive performance on tests of attention, learning and memory, executive functions and visual perception was found. In addition, there was a general trend towards cognitive enhancement from below average to average performance. These procognitive effects were independent of the antidepressant effects of NAcc-DBS or changes in NAcc-DBS parameters. These results not only support cognitive safety of NAcc-DBS but also stress its beneficial role in augmenting cognitive performance in patients with TRD.

Original languageEnglish (US)
Pages (from-to)516-527
Number of pages12
JournalWorld Journal of Biological Psychiatry
Volume12
Issue number7
StatePublished - Oct 2011
Externally publishedYes

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Deep Brain Stimulation
Nucleus Accumbens
Depression
Safety
Treatment-Resistant Depressive Disorder
Visual Perception
Executive Function
Antidepressive Agents
Learning
Language

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression : effects of 12-month stimulation. / Grubert, Christiane; Hurlemann, René; Bewernick, Bettina H.; Kayser, Sarah; Hadrysiewicz, Barbara; Axmacher, Nikolai; Sturm, Volker; Schlaepfer, Thomas E.

In: World Journal of Biological Psychiatry, Vol. 12, No. 7, 10.2011, p. 516-527.

Research output: Contribution to journalArticle

Grubert, C, Hurlemann, R, Bewernick, BH, Kayser, S, Hadrysiewicz, B, Axmacher, N, Sturm, V & Schlaepfer, TE 2011, 'Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: effects of 12-month stimulation.', World Journal of Biological Psychiatry, vol. 12, no. 7, pp. 516-527.
Grubert C, Hurlemann R, Bewernick BH, Kayser S, Hadrysiewicz B, Axmacher N et al. Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression: effects of 12-month stimulation. World Journal of Biological Psychiatry. 2011 Oct;12(7):516-527.
Grubert, Christiane ; Hurlemann, René ; Bewernick, Bettina H. ; Kayser, Sarah ; Hadrysiewicz, Barbara ; Axmacher, Nikolai ; Sturm, Volker ; Schlaepfer, Thomas E. / Neuropsychological safety of nucleus accumbens deep brain stimulation for major depression : effects of 12-month stimulation. In: World Journal of Biological Psychiatry. 2011 ; Vol. 12, No. 7. pp. 516-527.
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