Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation

Ravindra Arya; Celie Roth; James L. Leach; Denise Middeler; J. Adam Wilson; Jennifer Vannest; Leonid Rozhkov; Hansel M. Greiner; Jason Buroker; Craig Scholle; Hisako Fujiwara; Paul S. Horn; Douglas F. Rose; Nathan E. Crone; Francesco T. Mangano; Anna W. Byars; Katherine D. Holland

doi:10.1016/j.eplepsyres.2019.01.011

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation

Ravindra Arya, Celie Roth, James L. Leach, Denise Middeler, J. Adam Wilson, Jennifer Vannest, Leonid Rozhkov, Hansel M. Greiner, Jason Buroker, Craig Scholle, Hisako Fujiwara, Paul S. Horn, Douglas F. Rose, Nathan E. Crone, Francesco T. Mangano, Anna W. Byars, Katherine D. Holland

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Methods: Pediatric drug-resistant epilepsy (DRE) patients underwent pre-surgical language localization with ESM and HGM using a visual naming task. Surgical decisions were based solely on ESM results. NPE difference scores were compared between patients with/without resection of HGM naming sites using principal component (PC) analysis. Follow-up NPE scores were modeled with resection group as main effect and respective pre-surgical score as a covariate, using analysis of covariance. Results: Seventeen native English speakers (12 females), aged 6.5–20.2 years, were included. One year after epilepsy surgery, first PC score increased by (mean ± standard deviation) 14.4 ± 16.5 points in patients without resection, whereas it decreased by 7.6 ± 24.6 points in those with resection of HGM naming sites (p = 0.040). This PC score represented verbal comprehension, working memory, perceptual reasoning (Wechsler subscales); Woodcock-Johnson Tests of Achievement; and Peabody Picture Vocabulary Test. Subsequent analysis showed significant difference in working memory score between patients with/without resection of HGM naming sites (−15.2 points, 95% confidence limits −29.7 to −0.7, p = 0.041). Conclusion: We highlight the functional consequences of resecting HGM language sites, and suggest that NPE of DRE patients should include comprehensive assessment of multiple linguistic and cognitive domains besides naming ability.

Original language	English (US)
Pages (from-to)	17-23
Number of pages	7
Journal	Epilepsy Research
Volume	151
DOIs	https://doi.org/10.1016/j.eplepsyres.2019.01.011
State	Published - Mar 2019

Keywords

Epilepsy surgery
Functional brain mapping
Intracranial EEG
Neuropsychological evaluation

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.eplepsyres.2019.01.011

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Arya, R., Roth, C., Leach, J. L., Middeler, D., Wilson, J. A., Vannest, J., Rozhkov, L., Greiner, H. M., Buroker, J., Scholle, C., Fujiwara, H., Horn, P. S., Rose, D. F., Crone, N. E., Mangano, F. T., Byars, A. W., & Holland, K. D. (2019). Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation. Epilepsy Research, 151, 17-23. https://doi.org/10.1016/j.eplepsyres.2019.01.011

Arya, R, Roth, C, Leach, JL, Middeler, D, Wilson, JA, Vannest, J, Rozhkov, L, Greiner, HM, Buroker, J, Scholle, C, Fujiwara, H, Horn, PS, Rose, DF, Crone, NE, Mangano, FT, Byars, AW & Holland, KD 2019, 'Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation', Epilepsy Research, vol. 151, pp. 17-23. https://doi.org/10.1016/j.eplepsyres.2019.01.011

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title = "Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation",

abstract = "Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Methods: Pediatric drug-resistant epilepsy (DRE) patients underwent pre-surgical language localization with ESM and HGM using a visual naming task. Surgical decisions were based solely on ESM results. NPE difference scores were compared between patients with/without resection of HGM naming sites using principal component (PC) analysis. Follow-up NPE scores were modeled with resection group as main effect and respective pre-surgical score as a covariate, using analysis of covariance. Results: Seventeen native English speakers (12 females), aged 6.5–20.2 years, were included. One year after epilepsy surgery, first PC score increased by (mean ± standard deviation) 14.4 ± 16.5 points in patients without resection, whereas it decreased by 7.6 ± 24.6 points in those with resection of HGM naming sites (p = 0.040). This PC score represented verbal comprehension, working memory, perceptual reasoning (Wechsler subscales); Woodcock-Johnson Tests of Achievement; and Peabody Picture Vocabulary Test. Subsequent analysis showed significant difference in working memory score between patients with/without resection of HGM naming sites (−15.2 points, 95% confidence limits −29.7 to −0.7, p = 0.041). Conclusion: We highlight the functional consequences of resecting HGM language sites, and suggest that NPE of DRE patients should include comprehensive assessment of multiple linguistic and cognitive domains besides naming ability.",

keywords = "Epilepsy surgery, Functional brain mapping, Intracranial EEG, Neuropsychological evaluation",

author = "Ravindra Arya and Celie Roth and Leach, {James L.} and Denise Middeler and Wilson, {J. Adam} and Jennifer Vannest and Leonid Rozhkov and Greiner, {Hansel M.} and Jason Buroker and Craig Scholle and Hisako Fujiwara and Horn, {Paul S.} and Rose, {Douglas F.} and Crone, {Nathan E.} and Mangano, {Francesco T.} and Byars, {Anna W.} and Holland, {Katherine D.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = mar,

doi = "10.1016/j.eplepsyres.2019.01.011",

language = "English (US)",

volume = "151",

pages = "17--23",

journal = "Epilepsy Research",

issn = "0920-1211",

publisher = "Elsevier",

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T1 - Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation

AU - Arya, Ravindra

AU - Roth, Celie

AU - Leach, James L.

AU - Middeler, Denise

AU - Wilson, J. Adam

AU - Vannest, Jennifer

AU - Rozhkov, Leonid

AU - Greiner, Hansel M.

AU - Buroker, Jason

AU - Scholle, Craig

AU - Fujiwara, Hisako

AU - Horn, Paul S.

AU - Rose, Douglas F.

AU - Crone, Nathan E.

AU - Mangano, Francesco T.

AU - Byars, Anna W.

AU - Holland, Katherine D.

PY - 2019/3

Y1 - 2019/3

N2 - Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Methods: Pediatric drug-resistant epilepsy (DRE) patients underwent pre-surgical language localization with ESM and HGM using a visual naming task. Surgical decisions were based solely on ESM results. NPE difference scores were compared between patients with/without resection of HGM naming sites using principal component (PC) analysis. Follow-up NPE scores were modeled with resection group as main effect and respective pre-surgical score as a covariate, using analysis of covariance. Results: Seventeen native English speakers (12 females), aged 6.5–20.2 years, were included. One year after epilepsy surgery, first PC score increased by (mean ± standard deviation) 14.4 ± 16.5 points in patients without resection, whereas it decreased by 7.6 ± 24.6 points in those with resection of HGM naming sites (p = 0.040). This PC score represented verbal comprehension, working memory, perceptual reasoning (Wechsler subscales); Woodcock-Johnson Tests of Achievement; and Peabody Picture Vocabulary Test. Subsequent analysis showed significant difference in working memory score between patients with/without resection of HGM naming sites (−15.2 points, 95% confidence limits −29.7 to −0.7, p = 0.041). Conclusion: We highlight the functional consequences of resecting HGM language sites, and suggest that NPE of DRE patients should include comprehensive assessment of multiple linguistic and cognitive domains besides naming ability.

AB - Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Methods: Pediatric drug-resistant epilepsy (DRE) patients underwent pre-surgical language localization with ESM and HGM using a visual naming task. Surgical decisions were based solely on ESM results. NPE difference scores were compared between patients with/without resection of HGM naming sites using principal component (PC) analysis. Follow-up NPE scores were modeled with resection group as main effect and respective pre-surgical score as a covariate, using analysis of covariance. Results: Seventeen native English speakers (12 females), aged 6.5–20.2 years, were included. One year after epilepsy surgery, first PC score increased by (mean ± standard deviation) 14.4 ± 16.5 points in patients without resection, whereas it decreased by 7.6 ± 24.6 points in those with resection of HGM naming sites (p = 0.040). This PC score represented verbal comprehension, working memory, perceptual reasoning (Wechsler subscales); Woodcock-Johnson Tests of Achievement; and Peabody Picture Vocabulary Test. Subsequent analysis showed significant difference in working memory score between patients with/without resection of HGM naming sites (−15.2 points, 95% confidence limits −29.7 to −0.7, p = 0.041). Conclusion: We highlight the functional consequences of resecting HGM language sites, and suggest that NPE of DRE patients should include comprehensive assessment of multiple linguistic and cognitive domains besides naming ability.

KW - Epilepsy surgery

KW - Functional brain mapping

KW - Intracranial EEG

KW - Neuropsychological evaluation

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JO - Epilepsy Research

JF - Epilepsy Research

ER -

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation

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