Neuropsychological Functioning in Bipolar Disorder and Schizophrenia

David J. Schretlen, Nicola G. Cascella, Stephen M. Meyer, Lisle Kingery, S. Marc Testa, Cynthia A. Munro, Ann E Pulver, Paul Rivkin, Vani A. Rao, Catherine M. Diaz-Asper, Faith B. Dickerson, Robert H. Yolken, Godfrey Pearlson

Research output: Contribution to journalArticlepeer-review


Background: Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ). Methods: We compared the nature and severity of cognitive deficits shown by 106 patients with SZ and 66 patients with BD to 316 healthy adults (NC). All participants completed a cognitive battery with 19 individual measures. After adjusting their test performance for age, sex, race, education, and estimated premorbid IQ, we derived regression-based T-scores for each measure and the six cognitive domains. Results: Both patient groups performed significantly worse than NCs on most (BD) or all (SZ) cognitive tests and domains. The resulting effect sizes ranged from .37 to 1.32 (mean = .97) across tests for SZ patients and from .23 to .87 (mean = .59) for BD patients. The Pearson correlation of these effect sizes was .71 (p < .001). Conclusions: Patients with bipolar disorder suffer from cognitive deficits that are milder but qualitatively similar to those of patients with schizophrenia. These findings support the notion that schizophrenia and bipolar disorder show greater phenotypic similarity in terms of the nature than severity of their neuropsychological deficits.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalBiological psychiatry
Issue number2
StatePublished - Jul 15 2007


  • Biomarker
  • bipolar disorder
  • cognitive testing
  • neuropsychology
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry


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