TY - JOUR
T1 - Neuropsychological functioning and its relationship to antiphospholipid antibodies in patients with systemic lupus erythematosus
AU - Leritz, Elizabeth
AU - Brandt, Jason
AU - Minor, Melissa
AU - Reis-Jensen, Francis
AU - Petri, Michelle
N1 - Funding Information:
This work was supported, in part, by NIH grants NS1675, AG05146, RR00722, and AR 43727. The authors would like to thank Brian Tucker and Andrea Tamres for assistance in collection and management of data.
PY - 2002
Y1 - 2002
N2 - While it is clear that central nervous system (CNS) lesions in systemic lupus erythematosus (SLE) adversely affect cognitive functioning, it is also evident that patients without visible lesions (non-CNS SLE) may also exhibit subtle cognitive impairment. The presence of antiphospholipid antibodies (aPLs) has been proposed as a marker of disease severity and hence should be correlated with neuropsychological dysfunction in this population. The current study compared groups of non-CNS lupus patients who were positive (LA+) or negative (LA-) for aPLs on selected measures of neuropsychological functioning. In addition, we attempted to characterize the pattern of cognitive impairment that is associated with LA status in these patients. No coherent neuropsychological pattern emerged, but LA+ patients performed worse than LA- patients on measures assessing attention, concentration, and visual search, as well as spatial learning and memory.
AB - While it is clear that central nervous system (CNS) lesions in systemic lupus erythematosus (SLE) adversely affect cognitive functioning, it is also evident that patients without visible lesions (non-CNS SLE) may also exhibit subtle cognitive impairment. The presence of antiphospholipid antibodies (aPLs) has been proposed as a marker of disease severity and hence should be correlated with neuropsychological dysfunction in this population. The current study compared groups of non-CNS lupus patients who were positive (LA+) or negative (LA-) for aPLs on selected measures of neuropsychological functioning. In addition, we attempted to characterize the pattern of cognitive impairment that is associated with LA status in these patients. No coherent neuropsychological pattern emerged, but LA+ patients performed worse than LA- patients on measures assessing attention, concentration, and visual search, as well as spatial learning and memory.
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U2 - 10.1076/jcen.24.4.527.1038
DO - 10.1076/jcen.24.4.527.1038
M3 - Article
C2 - 12187465
AN - SCOPUS:0036070758
SN - 1380-3395
VL - 24
SP - 527
EP - 533
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 4
ER -