Neuropsychological Effects of Depression and Age in an Elderly Sample: A Confirmatory Study

Deborah A. King, Christopher Cox, Jeffrey M. Lyness, Eric D. Caine

Research output: Contribution to journalArticle

Abstract

Few well-controlled studies have directly examined the relationship of age and depression with neuropsychological function while at the same time examining the possible influence of general medical illness. Toward this end, 44 elderly patients with unipolar major depression were compared with 30 nondepressed controls with a range of neuropsychological tests. The depressed patients evidenced a broad base of deficits relative to controls, as well as more rapid declines with increasing age on tests of complex psychomotor function, copying, and perceptual integration. Overall level of general medical illness had minimal influence on neuropsychological test performance in either group. In light of recent reports contradictory to the findings presented here, the importance of participant selection variables in neuropsychological studies of late-life depression is discussed.

Original languageEnglish (US)
Pages (from-to)399-408
Number of pages10
JournalNeuropsychology
Volume9
Issue number3
StatePublished - Jul 1995
Externally publishedYes

Fingerprint

Neuropsychological Tests
Depression
Depressive Disorder

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

Cite this

Neuropsychological Effects of Depression and Age in an Elderly Sample : A Confirmatory Study. / King, Deborah A.; Cox, Christopher; Lyness, Jeffrey M.; Caine, Eric D.

In: Neuropsychology, Vol. 9, No. 3, 07.1995, p. 399-408.

Research output: Contribution to journalArticle

King, Deborah A. ; Cox, Christopher ; Lyness, Jeffrey M. ; Caine, Eric D. / Neuropsychological Effects of Depression and Age in an Elderly Sample : A Confirmatory Study. In: Neuropsychology. 1995 ; Vol. 9, No. 3. pp. 399-408.
@article{1e2f458a66574d8f878de8d6dbdfaddc,
title = "Neuropsychological Effects of Depression and Age in an Elderly Sample: A Confirmatory Study",
abstract = "Few well-controlled studies have directly examined the relationship of age and depression with neuropsychological function while at the same time examining the possible influence of general medical illness. Toward this end, 44 elderly patients with unipolar major depression were compared with 30 nondepressed controls with a range of neuropsychological tests. The depressed patients evidenced a broad base of deficits relative to controls, as well as more rapid declines with increasing age on tests of complex psychomotor function, copying, and perceptual integration. Overall level of general medical illness had minimal influence on neuropsychological test performance in either group. In light of recent reports contradictory to the findings presented here, the importance of participant selection variables in neuropsychological studies of late-life depression is discussed.",
author = "King, {Deborah A.} and Christopher Cox and Lyness, {Jeffrey M.} and Caine, {Eric D.}",
year = "1995",
month = "7",
language = "English (US)",
volume = "9",
pages = "399--408",
journal = "Neuropsychology",
issn = "0894-4105",
publisher = "American Psychological Association Inc.",
number = "3",

}

TY - JOUR

T1 - Neuropsychological Effects of Depression and Age in an Elderly Sample

T2 - A Confirmatory Study

AU - King, Deborah A.

AU - Cox, Christopher

AU - Lyness, Jeffrey M.

AU - Caine, Eric D.

PY - 1995/7

Y1 - 1995/7

N2 - Few well-controlled studies have directly examined the relationship of age and depression with neuropsychological function while at the same time examining the possible influence of general medical illness. Toward this end, 44 elderly patients with unipolar major depression were compared with 30 nondepressed controls with a range of neuropsychological tests. The depressed patients evidenced a broad base of deficits relative to controls, as well as more rapid declines with increasing age on tests of complex psychomotor function, copying, and perceptual integration. Overall level of general medical illness had minimal influence on neuropsychological test performance in either group. In light of recent reports contradictory to the findings presented here, the importance of participant selection variables in neuropsychological studies of late-life depression is discussed.

AB - Few well-controlled studies have directly examined the relationship of age and depression with neuropsychological function while at the same time examining the possible influence of general medical illness. Toward this end, 44 elderly patients with unipolar major depression were compared with 30 nondepressed controls with a range of neuropsychological tests. The depressed patients evidenced a broad base of deficits relative to controls, as well as more rapid declines with increasing age on tests of complex psychomotor function, copying, and perceptual integration. Overall level of general medical illness had minimal influence on neuropsychological test performance in either group. In light of recent reports contradictory to the findings presented here, the importance of participant selection variables in neuropsychological studies of late-life depression is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0029149995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029149995&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0029149995

VL - 9

SP - 399

EP - 408

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 3

ER -