The authors examined whether the baseline cognitive functioning of 21 clinically normal huntingtin mutation carriers who developed manifest Huntington's disease on follow-up differed from hat of 49 mutation carriers who remain asymptomatic over the same period in a longitudinal study. One hundred thirty-four gene-negative off spring of Huntington s disease patients were studied as well. Overall, there were no differences in cognitive test performance among the three groups. However, "converters" who developed signs of Huntington's disease within 8.6 years demonstrated poorer performance on the Wisconsin Card Sorting Test at baseline. People with the Huntington s disease mutation who are carefully examined neurologically and found to be asymptomatic have, at most, very minimal problem-solving impairment, and only if they are within a few years ofclinical onset.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Neuropsychiatry and Clinical Neurosciences|
|State||Published - Nov 2008|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health