Neuropsychological characteristics of mild cognitive impairment subgroups

Oscar L. Lopez, J. T. Becker, W. J. Jagust, A. Fitzpatrick, Michelle C Carlson, S. T. DeKosky, John C.S. Breitner, Constantine G Lyketsos, B. Jones, C. Kawas, L. H. Kuller

Research output: Contribution to journalArticle

Abstract

Objective: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study. Methods: MCI was classified as MCI-amnestic type (MCI-AT): patients with documented memory deficits but otherwise normal cognitive function; and MCI-multiple cognitive deficits type (MCI-MCDT): impairment of at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who had not crossed the dementia threshold. The MCI subjects did not have systemic, neurological, or psychiatric disorders likely to affect cognition. Results: MCI-AT (n = 10) had worse verbal and non-verbal memory performance than MCI-MCDT (n = 28) or normal controls (n = 374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function than MCI-AT or normal controls. MCI-MCDT subjects had memory deficits, though they were less pronounced than in MCI-AT. Of the MCI-MCDT cases, 22 (78.5%) had memory deficits, and 6 (21.5%) did not. MCI-MCDT with memory disorders had more language deficits than MCI-MCDT without memory disorders. By contrast, MCI-MCDT without memory deficits had more fine motor control deficits than MCI-MCDT with memory deficits. Conclusions: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups did not reflect the true prevalence of MCI in a population, as 16% of all MCI cases and 21.5% of the MCI-MCDT cases did not have memory impairment. Study of idiopathic amnestic and non-amnestic forms of MCI is essential for an understanding of the aetiology of MCI.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume77
Issue number2
DOIs
StatePublished - Feb 2006

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Memory Disorders
Cognitive Dysfunction
Cognition
Language
Dihydrotachysterol
Psychiatry
Dementia
Health
Population

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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Lopez, O. L., Becker, J. T., Jagust, W. J., Fitzpatrick, A., Carlson, M. C., DeKosky, S. T., ... Kuller, L. H. (2006). Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry, 77(2), 159-165. https://doi.org/10.1136/jnnp.2004.045567

Neuropsychological characteristics of mild cognitive impairment subgroups. / Lopez, Oscar L.; Becker, J. T.; Jagust, W. J.; Fitzpatrick, A.; Carlson, Michelle C; DeKosky, S. T.; Breitner, John C.S.; Lyketsos, Constantine G; Jones, B.; Kawas, C.; Kuller, L. H.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 77, No. 2, 02.2006, p. 159-165.

Research output: Contribution to journalArticle

Lopez, OL, Becker, JT, Jagust, WJ, Fitzpatrick, A, Carlson, MC, DeKosky, ST, Breitner, JCS, Lyketsos, CG, Jones, B, Kawas, C & Kuller, LH 2006, 'Neuropsychological characteristics of mild cognitive impairment subgroups', Journal of Neurology Neurosurgery and Psychiatry, vol. 77, no. 2, pp. 159-165. https://doi.org/10.1136/jnnp.2004.045567
Lopez, Oscar L. ; Becker, J. T. ; Jagust, W. J. ; Fitzpatrick, A. ; Carlson, Michelle C ; DeKosky, S. T. ; Breitner, John C.S. ; Lyketsos, Constantine G ; Jones, B. ; Kawas, C. ; Kuller, L. H. / Neuropsychological characteristics of mild cognitive impairment subgroups. In: Journal of Neurology Neurosurgery and Psychiatry. 2006 ; Vol. 77, No. 2. pp. 159-165.
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abstract = "Objective: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study. Methods: MCI was classified as MCI-amnestic type (MCI-AT): patients with documented memory deficits but otherwise normal cognitive function; and MCI-multiple cognitive deficits type (MCI-MCDT): impairment of at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who had not crossed the dementia threshold. The MCI subjects did not have systemic, neurological, or psychiatric disorders likely to affect cognition. Results: MCI-AT (n = 10) had worse verbal and non-verbal memory performance than MCI-MCDT (n = 28) or normal controls (n = 374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function than MCI-AT or normal controls. MCI-MCDT subjects had memory deficits, though they were less pronounced than in MCI-AT. Of the MCI-MCDT cases, 22 (78.5{\%}) had memory deficits, and 6 (21.5{\%}) did not. MCI-MCDT with memory disorders had more language deficits than MCI-MCDT without memory disorders. By contrast, MCI-MCDT without memory deficits had more fine motor control deficits than MCI-MCDT with memory deficits. Conclusions: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups did not reflect the true prevalence of MCI in a population, as 16{\%} of all MCI cases and 21.5{\%} of the MCI-MCDT cases did not have memory impairment. Study of idiopathic amnestic and non-amnestic forms of MCI is essential for an understanding of the aetiology of MCI.",
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T1 - Neuropsychological characteristics of mild cognitive impairment subgroups

AU - Lopez, Oscar L.

AU - Becker, J. T.

AU - Jagust, W. J.

AU - Fitzpatrick, A.

AU - Carlson, Michelle C

AU - DeKosky, S. T.

AU - Breitner, John C.S.

AU - Lyketsos, Constantine G

AU - Jones, B.

AU - Kawas, C.

AU - Kuller, L. H.

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N2 - Objective: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study. Methods: MCI was classified as MCI-amnestic type (MCI-AT): patients with documented memory deficits but otherwise normal cognitive function; and MCI-multiple cognitive deficits type (MCI-MCDT): impairment of at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who had not crossed the dementia threshold. The MCI subjects did not have systemic, neurological, or psychiatric disorders likely to affect cognition. Results: MCI-AT (n = 10) had worse verbal and non-verbal memory performance than MCI-MCDT (n = 28) or normal controls (n = 374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function than MCI-AT or normal controls. MCI-MCDT subjects had memory deficits, though they were less pronounced than in MCI-AT. Of the MCI-MCDT cases, 22 (78.5%) had memory deficits, and 6 (21.5%) did not. MCI-MCDT with memory disorders had more language deficits than MCI-MCDT without memory disorders. By contrast, MCI-MCDT without memory deficits had more fine motor control deficits than MCI-MCDT with memory deficits. Conclusions: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups did not reflect the true prevalence of MCI in a population, as 16% of all MCI cases and 21.5% of the MCI-MCDT cases did not have memory impairment. Study of idiopathic amnestic and non-amnestic forms of MCI is essential for an understanding of the aetiology of MCI.

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