Neuropsychiatric symptoms in Alzheimer's disease: What might be associated brain circuits?

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuropsychiatric symptoms (NPS) are very common in Alzheimer's disease (AD), particularly agitation, apathy, depression, and delusions. Brain networks or circuits underlying these symptoms are just starting to be understood, and there is a growing imaging and neurochemical evidence base for understanding potential mechanisms for NPS. We offer a synthetic review of the recent literature and offer hypotheses for potential networks/circuits underlying these NPS, particularly agitation, apathy, and delusions. Agitation in AD appears to be associated with deficits in structure and function of frontal cortex, anterior cingulate cortex, posterior cingulate cortex, amygdala, and hippocampus, and may be associated with mechanisms underlying misinterpretation of threats and affective regulation. Apathy in AD is associated with frontal cortex, anterior cingulate cortex, posterior cingulate cortex, as well as orbitofrontal cortex, and inferior temporal cortex, and may be associated with mechanisms underlying avoidance behaviors.

Original languageEnglish (US)
Pages (from-to)25-37
Number of pages13
JournalMolecular Aspects of Medicine
Volume43-44
DOIs
StatePublished - Jun 1 2015

Keywords

  • Agitation
  • Alzheimer's disease
  • Amygdala
  • Anterior cingulate cortex
  • Apathy
  • Delusions
  • Depression
  • Functional imaging
  • Inferior temporal cortex
  • Insula
  • Neuroimaging
  • Neuropsychiatric symptoms
  • Orbitrofrontal cortex
  • Posterior cingulate cortex

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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