Neuropsychiatric Effects of Anabolic Steroids in Male Normal Volunteers

Tung Ping Su, Michael Pagliaro, Peter J. Schmidt, David Pickar, Owen Wolkowitz, David R. Rubinow

Research output: Contribution to journalArticlepeer-review


Objective.—To evaluate the acute effects of anabolic steroids on mood and behavior in male normal volunteers. Design.—A 2-week, double-blind (subject and rater), fixed-order, placebo-controlled crossover trial of methyltestosterone. Setting.—An inpatient research unit at the National Institutes of Health. Subjects.—A volunteer sample of 20 men who were medication free, free of medical and psychiatric illness, not involved in athletic training, and had no prior history of anabolic steroid use. Intervention.—A sequential trial for 3 days each of the following four drug conditions: placebo baseline, low-dose methyltestosterone (40 mg/d), high-dose methyltestosterone (240 mg/d), and placebo withdrawal. Main Outcome Measures.—Mood and behavioral ratings were completed during each drug condition and included both subjective and objective measures. Results.—Significant (P

Original languageEnglish (US)
Pages (from-to)2760-2764
Number of pages5
JournalJournal of the American Medical Association
Issue number21
StatePublished - Jun 2 1993
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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