TY - JOUR
T1 - Neuropsychiatric dysfunction in primary Sjogren's syndrome
AU - Malinow, K. L.
AU - Molina, R.
AU - Gordon, B.
AU - Selnes, O. A.
AU - Provost, T. T.
AU - Alexander, E. L.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Neuropsychiatric complications developed in 40 patients with primary Sjogren's syndrome, none of whom met American Rheumatologic Association criteria for systemic lupus erythematosus. Twenty-five patients had psychiatric abnormalities, the commonest of which were affective disturbances. Of 30 patients tested, 23 had an abnormal pattern in the Minnesota Multiphasic Personality Inventory, the commonest pattern being a 'conversion V'. In general, patients presented with hysteroid dysphoric features. Of 16 patients undergoing cognitive function testing, 7 showed mild memory impairment with attention and concentration deficits. On clinical evaluation, 27 patients had neurologic abnormalities unattributable to other causes (central and peripheral nervous system in 16 and 19 patients respectively). There was a significant correlation between psychiatric disturbances and neurologic dysfunction, suggesting a possible organic basis for psychiatric dysfunction. The diagnosis of primary Sjogren's syndrome should be considered in patients with unexplained neuropsychiatric illness.
AB - Neuropsychiatric complications developed in 40 patients with primary Sjogren's syndrome, none of whom met American Rheumatologic Association criteria for systemic lupus erythematosus. Twenty-five patients had psychiatric abnormalities, the commonest of which were affective disturbances. Of 30 patients tested, 23 had an abnormal pattern in the Minnesota Multiphasic Personality Inventory, the commonest pattern being a 'conversion V'. In general, patients presented with hysteroid dysphoric features. Of 16 patients undergoing cognitive function testing, 7 showed mild memory impairment with attention and concentration deficits. On clinical evaluation, 27 patients had neurologic abnormalities unattributable to other causes (central and peripheral nervous system in 16 and 19 patients respectively). There was a significant correlation between psychiatric disturbances and neurologic dysfunction, suggesting a possible organic basis for psychiatric dysfunction. The diagnosis of primary Sjogren's syndrome should be considered in patients with unexplained neuropsychiatric illness.
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U2 - 10.7326/0003-4819-103-3-344
DO - 10.7326/0003-4819-103-3-344
M3 - Article
C2 - 2992332
AN - SCOPUS:0021971758
SN - 0003-4819
VL - 103
SP - 344
EP - 350
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 3
ER -