Neuropsychiatric Complications of Parkinson Disease Treatments: Importance of Multidisciplinary Care

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17 Scopus citations


Although Parkinson disease (PD) is defined clinically by its motor symptoms, it is increasingly recognized that much of the disability and worsened quality of life experienced by patients with PD is attributable to psychiatric symptoms. The authors describe a model of multidisciplinary care that enables these symptoms to be effectively managed. They describe neuropsychiatric complications of PD itself and pharmacologic and neurostimulation treatments for parkinsonian motor symptoms and discuss the management of these complications. Specifically, they describe the clinical associations between motor fluctuations and anxiety and depressive symptoms, the compulsive overuse of dopaminergic medications prescribed for motor symptoms (the dopamine dysregulation syndrome), and neuropsychiatric complications of these medications, including impulse control disorders, psychosis, and manic syndromes. Optimal management of these problems requires close collaboration across disciplines because of the potential for interactions among the pathophysiologic process of PD, motor symptoms, dopaminergic drugs, and psychiatric symptoms. The authors emphasize how their model of multidisciplinary care facilitates close collaboration among psychiatrists, other mental health professionals, neurologists, and functional neurosurgeons and how this facilitates effective care for patients who develop the specific neuropsychiatric complications discussed.

Original languageEnglish (US)
Pages (from-to)1171-1180
Number of pages10
JournalAmerican Journal of Geriatric Psychiatry
Issue number12
StatePublished - Dec 1 2016


  • anxiety
  • depression
  • dopamine replacement therapy (DRT)
  • multidisciplinary care
  • neuropsychiatric (symptoms), nonmotor (symptoms)
  • parkinson disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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