Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: Comparison with GDNF and persephin

Masako M. Bilak, David A. Shifrin, Andrea M. Corse, Stephan R. Bilak, Ralph W. Kuncl

Research output: Contribution to journalArticlepeer-review

Abstract

Neurturin and persephin are recently discovered homologs of glial cell line-derived neurotrophic factor (GDNF). Here, we report that neurturin, like GDNF, increases the choline acetyltransferase activity of normal postnatal motor neurons, induces neurite outgrowth in spinal cord, and potently protects motor neurons from chronic glutamate-mediated degeneration. Persephin, in contrast, does not appear to have neurotrophic or neurite- promoting effects on mature motor neurons and may instead worsen the glutamate injury of motor neurons. This pattern in the TGF-β family suggests certain receptor specificities, requiring at least the Ret/GFRα-1 receptor complex. The results predict potential benefit of neurturin, but not persephin, in the treatment of motor neuron disorders and spinal cord diseases.

Original languageEnglish (US)
Pages (from-to)326-336
Number of pages11
JournalMolecular and Cellular Neurosciences
Volume13
Issue number5
DOIs
StatePublished - May 1999

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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