Neuroprotective signaling and the aging brain

Take away my food and let me run

Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

It is remarkable that neurons are able to survive and function for a century or more in many persons that age successfully. A better understanding of the molecular signaling mechanisms that permit such cell survival and synaptic plasticity may therefore lead to the development of new preventative and therapeutic strategies for age-related neurodegenerative disorders. We all know that overeating and lack of exercise are risk factors for many different age-related diseases including cardiovascular disease, diabetes and cancers. Our recent studies have shown that dietary restriction (reduced calorie intake) can increase the resistance of neurons in the brain to dysfunction and death in experimental models of Alzheimer's disease, Parkinson's disease, Huntington's disease and stroke. The mechanism underlying the beneficial effects of dietary restriction involves stimulation of the expression of 'stress proteins' and neurotrophic factors. The neurotrophic factors induced by dietary restriction may protect neurons by inducing the production of proteins that suppress oxyradical production, stabilize cellular calcium homeostasis and inhibit apoptotic biochemical cascades. Interestingly, dietary restriction also increases numbers of newly-generated neural cells in the adult brain suggesting that this dietary manipulation can increase the brain's capacity for plasticity and self-repair. Work in other laboratories suggests that physical and intellectual activity can similarly increase neurotrophic factor production and neurogenesis. Collectively, the available data suggest the that dietary restriction, and physical and mental activity, may reduce both the incidence and severity of neurodegenerative disorders in humans. A better understanding of the cellular and molecular mechanisms underlying these effects of diet and behavior on the brain is also leading to novel therapeutic agents that mimick the beneficial effects of dietary restriction and exercise. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalBrain Research
Volume886
Issue number1-2
DOIs
StatePublished - Dec 15 2000
Externally publishedYes

Fingerprint

Nerve Growth Factors
Food
Brain
Neurons
Neurodegenerative Diseases
Hyperphagia
Neuronal Plasticity
Huntington Disease
Neurogenesis
Heat-Shock Proteins
Parkinson Disease
Cell Survival
Alzheimer Disease
Homeostasis
Theoretical Models
Cardiovascular Diseases
Stroke
Diet
Calcium
Incidence

Keywords

  • Alzheimer's disease
  • Calories
  • Development and regeneration
  • Genesis of neurons and glia
  • Heat shock protein
  • Mitochondria
  • Neurotrophic factor
  • Oxidative stress
  • Parkinson's disease
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroprotective signaling and the aging brain : Take away my food and let me run. / Mattson, Mark P.

In: Brain Research, Vol. 886, No. 1-2, 15.12.2000, p. 47-53.

Research output: Contribution to journalArticle

Mattson, Mark P. / Neuroprotective signaling and the aging brain : Take away my food and let me run. In: Brain Research. 2000 ; Vol. 886, No. 1-2. pp. 47-53.
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