Neuroprotective Roles of the Reverse Transsulfuration Pathway in Alzheimer’s Disease

Research output: Contribution to journalReview articlepeer-review

Abstract

The reverse transsulfuration pathway has emerged as a central hub that integrates the metabolism of sulfur-containing amino acids and redox homeostasis. Transsulfuration involves the transfer of sulfur from homocysteine to cysteine. Cysteine serves as the precursor for several sulfur-containing molecules, which play diverse roles in cellular processes. Recent evidence shows that disruption of the flux through the pathway has deleterious consequences. In this review article, I will discuss the actions and regulation of the reverse transsulfuration pathway and its links to other metabolic pathways, which are disrupted in Alzheimer’s disease (AD). The potential nodes of therapeutic intervention are also discussed, which may pave the way for the development of novel treatments.

Original languageEnglish (US)
Article number659402
JournalFrontiers in Aging Neuroscience
Volume13
DOIs
StatePublished - Mar 16 2021

Keywords

  • Alzheimer’s disease
  • cysteine
  • hydrogen sulfide
  • redox
  • sulfhydration/persulfidation
  • transsulfuration

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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