Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase

Ted M. Dawson, Kenneth Hung, Valina L. Dawson, Joseph P. Steiner, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Gangliosides are polar, sugar‐containing lipids that are major constituents of neuronal membranes. Gangliosides are neuroprotective in animal models of neurotoxicity and may also be useful in patients with clinical conditions such as spinal cord injury. We show that a series of gangliosides inhibit nitric oxide synthase activity by binding calmodulin. The prevention of glutamate neurotoxicity in cortical cultures by gangliosides closely parallels their potencies in binding calmodulin and inhibiting nitric oxide synthase. Neuroprotective effects of gangliosides may arise from blockade of nitric oxide formation.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalAnnals of neurology
Volume37
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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