Neuroprotective effects of an erythropoietin-derived peptide in PC1 2 cells under oxidative stress

Seung Jun Yoo, Bongki Cho, Chanil Moon, Seong Woon Yu, Cheil Moon

Research output: Contribution to journalArticle

Abstract

Erythropoietin (EPO) has been shown to be a key cytokine in the production of erythrocytes from erythroblasts. Recently, attempts have been made to adopt EPO as a drug target for neuroprotection in selected neurological pathologies. In the current study, a novel EPO-derived peptide which mimics the weak binding site of EPO to its receptor (MK-X) was generated. Experimental results demonstrated that MK-X was able to ameliorate neuronal death due to reactive oxygen species and conditions of oxidative stress similar to EPO. In addition, MK-X induced long-lasting Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and Akt activation. Furthermore, treatment with inhibitors of ERK1/2 and Akt abolished the neuroprotective effect of MK-X. Unlike EPO, however, MK-X did not induce cellular proliferation. Collectively, the results of the current study suggested that MK-X may be useful as a novel neuroprotective reagent.

Original languageEnglish (US)
Pages (from-to)927-934
Number of pages8
JournalCNS and Neurological Disorders - Drug Targets
Volume15
Issue number9
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • Erythropoietin
  • Erythropoietin receptor
  • Neuronal death
  • Peptide
  • Proliferation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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