Neuroprotective Effect of Felbamate After Kainic Acid‐Induced Status Epilepticus

Antonia Chronopoulos, Carl Stafstrom, Sam Thurber, Pamela Hyde, Mohamad Mikati, Gregory L. Holmes

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: Felbamate (FBM), a newly developed antiepileptic drug (AED), was previously shown to offer some neuroprotective effects against hypoxic injury in both in vivo and in vitro studies. We administered FBM (100 or 300 mg/kg) to 30‐day‐old rats 1 h after they received a convulsant dosage of kainic acid (KA). Animals were then tested at age 80 days in the water maze, open field, and handling tests. Seizure latency was then tested by flurothyl inhalation. Animals that received 300 mg/kg FBM performed better in all three tests and had longer latencies to flurothyl‐induced seizures than did animals that received vehicle. This study suggests that FBM may have some neuroprotective effects after KA‐induced status epilepticus (SE).

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalEpilepsia
Volume34
Issue number2
DOIs
StatePublished - Mar 1993
Externally publishedYes

Keywords

  • Anticonvulsants
  • Convulsions
  • Epilepsy
  • Felbamate
  • Kainic acid
  • Neurologic models

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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