Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

Dong Liu; Liejun Wu; Richard Breyer; Mark P. Mattson; Katrin Andreasson

doi:10.1002/ana.20461

Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

Dong Liu, Liejun Wu, Richard Breyer, Mark P. Mattson, Katrin Andreasson

School of Medicine

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Recent studies suggest a neuroprotective function of the PGE₂ EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke.

Original language	English (US)
Pages (from-to)	758-761
Number of pages	4
Journal	Annals of Neurology
Volume	57
Issue number	5
DOIs	https://doi.org/10.1002/ana.20461
State	Published - May 2005

ASJC Scopus subject areas

General Neuroscience

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title = "Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia",

abstract = "Recent studies suggest a neuroprotective function of the PGE2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke.",

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AB - Recent studies suggest a neuroprotective function of the PGE2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke.

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Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

Abstract

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