Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

Dong Liu, Liejun Wu, Richard Breyer, Mark P. Mattson, Katrin Andreasson

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies suggest a neuroprotective function of the PGE2 EP2 receptor in excitotoxic neuronal injury. The function of the EP2 receptor was examined at time points after excitotoxicity in an organotypic hippocampal model of N-methyl-D-aspartate (NMDA) challenge and in a permanent model of focal forebrain ischemia. Activation of EP2 led to significant neuroprotection in hippocampal slices up to 3 hours after a toxic NMDA stimulus. Genetic deletion of EP2 resulted in a marked increase in stroke volume in the permanent middle cerebral artery occlusion model. These findings support further investigation into therapeutic strategies targeting the EP2 receptor in stroke.

Original languageEnglish (US)
Pages (from-to)758-761
Number of pages4
JournalAnnals of Neurology
Volume57
Issue number5
DOIs
StatePublished - May 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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