Abstract
Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPARs, and Sema3F regulates this interaction. Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. Regulation of AMPA-type glutamate receptor number at synapses underlies modulation of synaptic strength during homeostatic scaling. Wang et al. show that the secreted protein semaphorin 3F (Sema3F) and its neuropilin-2/plexinA3 holoreceptor mediate homeostatic plasticity in cortical neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1084-1098.e7 |
| Journal | Neuron |
| Volume | 96 |
| Issue number | 5 |
| DOIs | |
| State | Published - Dec 6 2017 |
Fingerprint
Keywords
- AMPA receptor
- homeostatic plasticity
- Neuropilin-2
- Plexin receptor
- Sema3F
- semaphorin
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. / Wang, Qiang; Chiu, Shu-Ling; Koropouli, Eleftheria; Hong, Ingie; Mitchell, Sarah; Easwaran, Teresa P.; Hamilton, Natalie R.; Gustina, Ahleah S.; Zhu, Qianwen; Ginty, David D.; Huganir, Richard L; Kolodkin, Alex L.
In: Neuron, Vol. 96, No. 5, 06.12.2017, p. 1084-1098.e7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons
AU - Wang, Qiang
AU - Chiu, Shu-Ling
AU - Koropouli, Eleftheria
AU - Hong, Ingie
AU - Mitchell, Sarah
AU - Easwaran, Teresa P.
AU - Hamilton, Natalie R.
AU - Gustina, Ahleah S.
AU - Zhu, Qianwen
AU - Ginty, David D.
AU - Huganir, Richard L
AU - Kolodkin, Alex L
PY - 2017/12/6
Y1 - 2017/12/6
N2 - Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPARs, and Sema3F regulates this interaction. Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. Regulation of AMPA-type glutamate receptor number at synapses underlies modulation of synaptic strength during homeostatic scaling. Wang et al. show that the secreted protein semaphorin 3F (Sema3F) and its neuropilin-2/plexinA3 holoreceptor mediate homeostatic plasticity in cortical neurons.
AB - Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPARs, and Sema3F regulates this interaction. Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. Regulation of AMPA-type glutamate receptor number at synapses underlies modulation of synaptic strength during homeostatic scaling. Wang et al. show that the secreted protein semaphorin 3F (Sema3F) and its neuropilin-2/plexinA3 holoreceptor mediate homeostatic plasticity in cortical neurons.
KW - AMPA receptor
KW - homeostatic plasticity
KW - Neuropilin-2
KW - Plexin receptor
KW - Sema3F
KW - semaphorin
UR - http://www.scopus.com/inward/record.url?scp=85034456241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034456241&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2017.10.029
DO - 10.1016/j.neuron.2017.10.029
M3 - Article
C2 - 29154130
AN - SCOPUS:85034456241
VL - 96
SP - 1084-1098.e7
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 5
ER -