Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

Qiang Wang, Shu-Ling Chiu, Eleftheria Koropouli, Ingie Hong, Sarah Mitchell, Teresa P. Easwaran, Natalie R. Hamilton, Ahleah S. Gustina, Qianwen Zhu, David D. Ginty, Richard L Huganir, Alex L Kolodkin

Research output: Contribution to journalArticle

Abstract

Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons. Sema3F-Npn-2/PlexA3 signaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in neuronal activity, Npn-2 associates with AMPARs, and Sema3F regulates this interaction. Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. Regulation of AMPA-type glutamate receptor number at synapses underlies modulation of synaptic strength during homeostatic scaling. Wang et al. show that the secreted protein semaphorin 3F (Sema3F) and its neuropilin-2/plexinA3 holoreceptor mediate homeostatic plasticity in cortical neurons.

Original languageEnglish (US)
Pages (from-to)1084-1098.e7
JournalNeuron
Volume96
Issue number5
DOIs
StatePublished - Dec 6 2017

Fingerprint

Neuropilin-2
Semaphorins
AMPA Receptors
Glutamate Receptors
Neurons
Synapses
Neuronal Plasticity
Cues

Keywords

  • AMPA receptor
  • homeostatic plasticity
  • Neuropilin-2
  • Plexin receptor
  • Sema3F
  • semaphorin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. / Wang, Qiang; Chiu, Shu-Ling; Koropouli, Eleftheria; Hong, Ingie; Mitchell, Sarah; Easwaran, Teresa P.; Hamilton, Natalie R.; Gustina, Ahleah S.; Zhu, Qianwen; Ginty, David D.; Huganir, Richard L; Kolodkin, Alex L.

In: Neuron, Vol. 96, No. 5, 06.12.2017, p. 1084-1098.e7.

Research output: Contribution to journalArticle

Wang, Q, Chiu, S-L, Koropouli, E, Hong, I, Mitchell, S, Easwaran, TP, Hamilton, NR, Gustina, AS, Zhu, Q, Ginty, DD, Huganir, RL & Kolodkin, AL 2017, 'Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons', Neuron, vol. 96, no. 5, pp. 1084-1098.e7. https://doi.org/10.1016/j.neuron.2017.10.029
Wang, Qiang ; Chiu, Shu-Ling ; Koropouli, Eleftheria ; Hong, Ingie ; Mitchell, Sarah ; Easwaran, Teresa P. ; Hamilton, Natalie R. ; Gustina, Ahleah S. ; Zhu, Qianwen ; Ginty, David D. ; Huganir, Richard L ; Kolodkin, Alex L. / Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. In: Neuron. 2017 ; Vol. 96, No. 5. pp. 1084-1098.e7.
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