Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons

Jean François Cloutier, Roman J. Giger, Georgy Koentges, Catherine Dulac, Alex L Kolodkin, David D. Ginty

Research output: Contribution to journalArticle

Abstract

The mechanisms that underlie axonal pathfinding of vomeronasal neurons from the vomeronasal organ (VNO) in the periphery to select glomeruli in the accessory olfactory bulb (AOB) are not well understood. Neuropilin-2, a receptor for secreted semaphorins, is expressed in V1R- and V3R-expressing, but not V2R-expressing, postnatal vomeronasal neurons. Analysis of the vomeronasal nerve in neuropilin-2 (npn-2) mutant mice reveals pathfinding defects at multiple choice points. Vomeronasal sensory axons are severely defasciculated and a subset innervates the main olfactory bulb (MOB). While most axons of V1R-expressing neurons reach the AOB and converge into distinct glomeruli in stereotypic locations, they are no longer restricted to their normal anterior AOB target zone. Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system.

Original languageEnglish (US)
Pages (from-to)877-892
Number of pages16
JournalNeuron
Volume33
Issue number6
DOIs
StatePublished - Mar 14 2002

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Neuropilin-2
Olfactory Bulb
Vomeronasal Organ
Neurons
Axons
Pheromone Receptors
Semaphorins
Sensory Receptor Cells
Axon Fasciculation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. / Cloutier, Jean François; Giger, Roman J.; Koentges, Georgy; Dulac, Catherine; Kolodkin, Alex L; Ginty, David D.

In: Neuron, Vol. 33, No. 6, 14.03.2002, p. 877-892.

Research output: Contribution to journalArticle

Cloutier, Jean François ; Giger, Roman J. ; Koentges, Georgy ; Dulac, Catherine ; Kolodkin, Alex L ; Ginty, David D. / Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. In: Neuron. 2002 ; Vol. 33, No. 6. pp. 877-892.
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