Neuropeptides in human brain-postmortem studies

Joel E. Kleinman, John Hong, Michael Iadarola, Stefano Govoni, Christian J. Gillin

Research output: Contribution to journalArticlepeer-review

Abstract

Kleinman, Joel E., John Hong, Michael Iadarola, Stefano Govoni, and J. Christian Gillin: Neuropeptides in human brain - postmortem studies. Prog. Neuro-Psychopharmacol. and Biol. Psychiatry: 1985, 9 (1): 91-95. 1. 1. Four neuropeptides (substance P, methionine-enkephalin, neurotensin and cholecystokinin) were measured by radioimmunoassays in a number of brain regions of deceased patients with mental illnesses and controls. 2. 2. The most striking finding in these studies was that methionine-enkephalin concentrations in caudate nuclei of chronic paranoid schizophrenic patients were reduced relative to several control groups. 3. 3. Neuroleptics had no obvious effects on any of the four measured neuropeptides. 4. 4. These findings are not inconsistent with the hypothesis that methionine-enkephalin may be involved in some of the pathology of the schizophrenic syndrome.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume9
Issue number1
DOIs
StatePublished - 1985
Externally publishedYes

Keywords

  • alcoholism
  • heroin addiction
  • neuropeptides
  • postmortem studies
  • schizophrenia
  • suicide

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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