Neuropeptide Y expression distinguishes malignant from benign pheochromocytoma

L. J. Helman; P. S. Cohen; S. D. Averbuch; M. J. Cooper; H. R. Keiser; M. A. Israel

doi:10.1200/JCO.1989.7.11.1720

Neuropeptide Y expression distinguishes malignant from benign pheochromocytoma

L. J. Helman, P. S. Cohen, S. D. Averbuch, M. J. Cooper, H. R. Keiser, M. A. Israel

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Abstract

No reliable gross or microscopic features distinguish benign from malignant pheochromocytomas. The diagnosis of malignant pheochromocytoma is based solely on the presence of regional or distant metastases. This study evaluated the expression of neuropeptide Y messenger RNA (mRNA) in nine benign and 11 malignant pheochromocytomas and has found that neuropeptide Y mRNA was expressed in all nine benign tumors but in only four of 11 malignant tumors (P = .0084). These data suggest that the determination of neuropeptide Y expression in the evaluation of patients with pheochromocytoma may have prognostic significance.

Original language	English (US)
Pages (from-to)	1720-1725
Number of pages	6
Journal	Journal of Clinical Oncology
Volume	7
Issue number	11
DOIs	https://doi.org/10.1200/JCO.1989.7.11.1720
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1200/JCO.1989.7.11.1720

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title = "Neuropeptide Y expression distinguishes malignant from benign pheochromocytoma",

abstract = "No reliable gross or microscopic features distinguish benign from malignant pheochromocytomas. The diagnosis of malignant pheochromocytoma is based solely on the presence of regional or distant metastases. This study evaluated the expression of neuropeptide Y messenger RNA (mRNA) in nine benign and 11 malignant pheochromocytomas and has found that neuropeptide Y mRNA was expressed in all nine benign tumors but in only four of 11 malignant tumors (P = .0084). These data suggest that the determination of neuropeptide Y expression in the evaluation of patients with pheochromocytoma may have prognostic significance.",

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AU - Helman, L. J.

AU - Cohen, P. S.

AU - Averbuch, S. D.

AU - Cooper, M. J.

AU - Keiser, H. R.

AU - Israel, M. A.

PY - 1989

Y1 - 1989

N2 - No reliable gross or microscopic features distinguish benign from malignant pheochromocytomas. The diagnosis of malignant pheochromocytoma is based solely on the presence of regional or distant metastases. This study evaluated the expression of neuropeptide Y messenger RNA (mRNA) in nine benign and 11 malignant pheochromocytomas and has found that neuropeptide Y mRNA was expressed in all nine benign tumors but in only four of 11 malignant tumors (P = .0084). These data suggest that the determination of neuropeptide Y expression in the evaluation of patients with pheochromocytoma may have prognostic significance.

AB - No reliable gross or microscopic features distinguish benign from malignant pheochromocytomas. The diagnosis of malignant pheochromocytoma is based solely on the presence of regional or distant metastases. This study evaluated the expression of neuropeptide Y messenger RNA (mRNA) in nine benign and 11 malignant pheochromocytomas and has found that neuropeptide Y mRNA was expressed in all nine benign tumors but in only four of 11 malignant tumors (P = .0084). These data suggest that the determination of neuropeptide Y expression in the evaluation of patients with pheochromocytoma may have prognostic significance.

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JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

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Neuropeptide Y expression distinguishes malignant from benign pheochromocytoma

Abstract

ASJC Scopus subject areas

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