Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: Its downregulation by DISC1

Adriana Ramos, Carmen Rodríguez-Seoane, Isaac Rosa, Svenja V. Trossbach, Alfredo Ortega-Alonso, Liisa Tomppo, Jesper Ekelund, Juha Veijola, Marjo Riitta Järvelin, Jana Alonso, Sonia Veiga, Akira Sawa, William Hennah, Ángel García, Carsten Korth, Jesús R. Requena

Research output: Contribution to journalArticle

Abstract

In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. Thus, study of DISC1mayprovidea clue to understand the biology of major mental illness. A neuropeptide precursor VGF has potent antidepressant effects and has been reportedly associated with bipolar disorder. Here we show that DISC1 knockdown leads to a reduction of VGF, in neurons. VGF is also downregulated in the cortices from sporadic cases with major mental disease. A positive correlation of VGF single-nucleotide polymorphisms (SNPs) with social anhedonia was also observed. We now propose that VGF participates in a common pathophysiology of major mental disease.

Original languageEnglish (US)
Pages (from-to)5859-5865
Number of pages7
JournalHuman molecular genetics
Volume23
Issue number22
DOIs
StatePublished - Nov 15 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: Its downregulation by DISC1'. Together they form a unique fingerprint.

  • Cite this

    Ramos, A., Rodríguez-Seoane, C., Rosa, I., Trossbach, S. V., Ortega-Alonso, A., Tomppo, L., Ekelund, J., Veijola, J., Järvelin, M. R., Alonso, J., Veiga, S., Sawa, A., Hennah, W., García, Á., Korth, C., & Requena, J. R. (2014). Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: Its downregulation by DISC1. Human molecular genetics, 23(22), 5859-5865. https://doi.org/10.1093/hmg/ddu303