Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Juan C. Troncoso, Anne M. Cataldo, Ralph A. Nixon, Jody L. Barnett, Michael K. Lee, Frederic Checler, David R. Fowler, John E. Smialek, Barbara Crain, Lee J. Martin, Claudia H. Kawas

Research output: Contribution to journalArticlepeer-review


We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal- lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
JournalAnnals of neurology
Issue number5
StatePublished - May 1998

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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