Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Juan C. Troncoso; Anne M. Cataldo; Ralph A. Nixon; Jody L. Barnett; Michael K. Lee; Frederic Checler; David R. Fowler; John E. Smialek; Barbara Crain; Lee J. Martin; Claudia H. Kawas

doi:10.1002/ana.410430519

Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Juan C. Troncoso, Anne M. Cataldo, Ralph A. Nixon, Jody L. Barnett, Michael K. Lee, Frederic Checler, David R. Fowler, John E. Smialek, Barbara Crain, Lee J. Martin, Claudia H. Kawas

School of Medicine

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal- lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

Original language	English (US)
Pages (from-to)	673-676
Number of pages	4
Journal	Annals of neurology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1002/ana.410430519
State	Published - May 1998

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Neuropathology of preclinical and clinical late-onset Alzheimer's disease",

abstract = "We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal- lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.",

author = "Troncoso, {Juan C.} and Cataldo, {Anne M.} and Nixon, {Ralph A.} and Barnett, {Jody L.} and Lee, {Michael K.} and Frederic Checler and Fowler, {David R.} and Smialek, {John E.} and Barbara Crain and Martin, {Lee J.} and Kawas, {Claudia H.}",

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T1 - Neuropathology of preclinical and clinical late-onset Alzheimer's disease

AU - Troncoso, Juan C.

AU - Cataldo, Anne M.

AU - Nixon, Ralph A.

AU - Barnett, Jody L.

AU - Lee, Michael K.

AU - Checler, Frederic

AU - Fowler, David R.

AU - Smialek, John E.

AU - Crain, Barbara

AU - Martin, Lee J.

AU - Kawas, Claudia H.

PY - 1998/5

Y1 - 1998/5

N2 - We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal- lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

AB - We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal- lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

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Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Abstract

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