Neuropathology of explosive blast traumatic brain injury

John Magnuson, Fabio Leonessa, Geoffrey Ling

Research output: Contribution to journalReview article

Abstract

During the conflicts of the Global War on Terror, which are Operation Enduring Freedom (OEF) in Afghanistan and Operation Iraqi Freedom (OIF), there have been over a quarter of a million diagnosed cases of traumatic brain injury (TBI). The vast majority are due to explosive blast. Although explosive blast TBI (bTBI) shares many clinical features with closed head TBI (cTBI) and penetrating TBI (pTBI), it has unique features, such as early cerebral edema and prolonged cerebral vasospasm. Evolving work suggests that diffuse axonal injury (DAI) seen following explosive blast exposure is different than DAI from focal impact injury. These unique features support the notion that bTBI is a separate and distinct form of TBI. This review summarizes the current state of knowledge pertaining to bTBI. Areas of discussion are: the physics of explosive blast generation, blast wave interaction with the bony calvarium and brain tissue, gross tissue pathophysiology, regional brain injury, and cellular and molecular mechanisms of explosive blast neurotrauma.

Original languageEnglish (US)
Pages (from-to)570-579
Number of pages10
JournalCurrent Neurology and Neuroscience Reports
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Fingerprint

Diffuse Axonal Injury
2003-2011 Iraq War
Penetrating Head Injuries
Afghan Campaign 2001-
Afghanistan
Intracranial Vasospasm
Brain Edema
Physics
Skull
Brain Injuries
Head
Traumatic Brain Injury
Neuropathology
Wounds and Injuries
Brain

Keywords

  • Cognitive function
  • DTI
  • Explosive blast
  • Histology
  • Pathology
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Neuropathology of explosive blast traumatic brain injury. / Magnuson, John; Leonessa, Fabio; Ling, Geoffrey.

In: Current Neurology and Neuroscience Reports, Vol. 12, No. 5, 01.10.2012, p. 570-579.

Research output: Contribution to journalReview article

Magnuson, John ; Leonessa, Fabio ; Ling, Geoffrey. / Neuropathology of explosive blast traumatic brain injury. In: Current Neurology and Neuroscience Reports. 2012 ; Vol. 12, No. 5. pp. 570-579.
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