Neuropathology of cocaine abuse

Research output: Contribution to journalArticle

Abstract

The effects of cocaine abuse on brain structure and function are numerous. Some of these effects, such as catastrophic cerebrovascular incidents, are clearly neuropathological. Others, such as persistent perfusion deficits and changes in cerebral glucose utilization, await further functional definition. More recent findings of increases in dopamine transpoter density and gene induction may be neuropathologic, but could represent neuroadaptive responses to cocaine's acute actions of cocaine, manifestations of the reinforcing properties of cocaine or epiphenomena of addiction. Recent technical advances directed at bridging the gap between preclinical and clinical studies hold significant promise for advancing our understanding regarding the neuropathology of cocaine abuse and addiction.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalCurrent Opinion in Psychiatry
Volume12
Issue number3
DOIs
StatePublished - 1999

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Cocaine-Related Disorders
Cocaine
Dopamine
Perfusion
Glucose
Brain
Genes
Neuropathology

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Neuropathology of cocaine abuse. / McCann, Una D; Ricaurte, George.

In: Current Opinion in Psychiatry, Vol. 12, No. 3, 1999, p. 277-280.

Research output: Contribution to journalArticle

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