Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

W. Robert Bell, Yang An, Yusuke Kageyama, Collin English, Gay L. Rudow, Olga Pletnikova, Madhav Thambisetty, Richard O'Brien, Abhay R Moghekar, Marilyn Albert, Peter V Rabins, Susan M. Resnick, Juan C Troncoso

Research output: Contribution to journalArticle

Abstract

Introduction: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Methods: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. Results: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P =.0046). Discussion: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Tauopathies
Alzheimer Disease
Apolipoprotein E4
Baltimore
Health Planning
Apolipoproteins E
Gene Frequency
Haplotypes
Longitudinal Studies
Autopsy
Language
Public Health
Genotype
Pathology
Delivery of Health Care
Brain
Research

Keywords

  • Aging
  • Alzheimer disease (AD)
  • Dementia
  • Mild Cognitive Impairment (MCI)
  • Neurofibrillary tangles
  • Primary Age-Related Tauopathy (PART)
  • Public Health Planning

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease. / Bell, W. Robert; An, Yang; Kageyama, Yusuke; English, Collin; Rudow, Gay L.; Pletnikova, Olga; Thambisetty, Madhav; O'Brien, Richard; Moghekar, Abhay R; Albert, Marilyn; Rabins, Peter V; Resnick, Susan M.; Troncoso, Juan C.

In: Alzheimer's and Dementia, 01.01.2018.

Research output: Contribution to journalArticle

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