Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

W. Robert Bell, Yang An, Yusuke Kageyama, Collin English, Gay L. Rudow, Olga Pletnikova, Madhav Thambisetty, Richard O'Brien, Abhay R. Moghekar, Marilyn S. Albert, Peter V. Rabins, Susan M. Resnick, Juan C. Troncoso

Research output: Contribution to journalArticle

Abstract

Introduction: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. Methods: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. Results: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P =.0046). Discussion: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalAlzheimer's and Dementia
Volume15
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • Aging
  • Alzheimer disease (AD)
  • Dementia
  • Mild Cognitive Impairment (MCI)
  • Neurofibrillary tangles
  • Primary Age-Related Tauopathy (PART)
  • Public Health Planning

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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