Neuropathic Pain

Jasenka Borzan, R. A. Meyer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Certain diseases, chemotherapy, or nerve traumas can lead to pathology in the peripheral or central nervous system that causes chronic neuropathic pain. Peripheral and central nociceptive neurons exhibit spontaneous activity and enhanced responsiveness to natural stimulation of their receptive fields. Complex pathological changes occur, including alterations in the distribution of ion channels, growth factors, and neuropeptides; novel interactions between sympathetic fibers and nociceptors; the activation of peripheral and central immune cells; and the synthesis and release of proinflammatory factors. An understanding of the mechanisms underlying neuropathic pain provides the basis for the development of novel therapeutic strategies.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages749-757
Number of pages9
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Animal model
  • Central pain
  • Chemotherapy
  • Cytokines
  • Diabetic neuropathy
  • Ectopic activity
  • Immune cells
  • Nerve injury
  • Neuropathic pain
  • Neuropathy
  • Pathology
  • Postherpetic neuralgia
  • Sensitization
  • Sodium channels
  • Sympathetically maintained pain
  • Trauma
  • Wallerian degeneration

ASJC Scopus subject areas

  • Neuroscience(all)

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