Abstract
Identifying and harnessing regenerative pathways while suppressing the growth-inhibiting processes of the biological response to injury is the central goal of stimulating neurogenesis after central nervous system (CNS)injury. However, due to the complexity of the mature CNS involving a plethora of cellular pathways and extracellular cues, as well as difficulties in accessibility without highly invasive procedures, clinical successes of regenerative medicine for CNS injuries have been extremely limited. Current interventions primarily focus on stabilization and mitigation of further neuronal death rather than direct stimulation of neurogenesis. In the past few decades, nanotechnology has offered substantial innovations to the field of regenerative medicine. Their nanoscale features allow for the fine tuning of biological interactions for enhancing drug delivery and stimulating cellular processes. This review gives an overview of nanotechnology applications in CNS regeneration organized according to cellular and extracellular targets and discuss future directions for the field.
| Original language | English (US) |
|---|---|
| Journal | Advanced Drug Delivery Reviews |
| DOIs | |
| State | Published - Jan 1 2019 |
Fingerprint
Keywords
- Brain injury
- Extracellular matrix
- Nanotechnology
- Neurogenesis
- Regenerative medicine
- Targeted drug delivery
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Neuronanotechnology for brain regeneration. / Liaw, Kevin; Zhang, Zhi; Kannan, Sujatha.
In: Advanced Drug Delivery Reviews, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuronanotechnology for brain regeneration
AU - Liaw, Kevin
AU - Zhang, Zhi
AU - Kannan, Sujatha
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Identifying and harnessing regenerative pathways while suppressing the growth-inhibiting processes of the biological response to injury is the central goal of stimulating neurogenesis after central nervous system (CNS)injury. However, due to the complexity of the mature CNS involving a plethora of cellular pathways and extracellular cues, as well as difficulties in accessibility without highly invasive procedures, clinical successes of regenerative medicine for CNS injuries have been extremely limited. Current interventions primarily focus on stabilization and mitigation of further neuronal death rather than direct stimulation of neurogenesis. In the past few decades, nanotechnology has offered substantial innovations to the field of regenerative medicine. Their nanoscale features allow for the fine tuning of biological interactions for enhancing drug delivery and stimulating cellular processes. This review gives an overview of nanotechnology applications in CNS regeneration organized according to cellular and extracellular targets and discuss future directions for the field.
AB - Identifying and harnessing regenerative pathways while suppressing the growth-inhibiting processes of the biological response to injury is the central goal of stimulating neurogenesis after central nervous system (CNS)injury. However, due to the complexity of the mature CNS involving a plethora of cellular pathways and extracellular cues, as well as difficulties in accessibility without highly invasive procedures, clinical successes of regenerative medicine for CNS injuries have been extremely limited. Current interventions primarily focus on stabilization and mitigation of further neuronal death rather than direct stimulation of neurogenesis. In the past few decades, nanotechnology has offered substantial innovations to the field of regenerative medicine. Their nanoscale features allow for the fine tuning of biological interactions for enhancing drug delivery and stimulating cellular processes. This review gives an overview of nanotechnology applications in CNS regeneration organized according to cellular and extracellular targets and discuss future directions for the field.
KW - Brain injury
KW - Extracellular matrix
KW - Nanotechnology
KW - Neurogenesis
KW - Regenerative medicine
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85066043105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066043105&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2019.04.004
DO - 10.1016/j.addr.2019.04.004
M3 - Article
AN - SCOPUS:85066043105
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -