TY - JOUR
T1 - Neuronanotechnology for brain regeneration
AU - Liaw, Kevin
AU - Zhang, Zhi
AU - Kannan, Sujatha
N1 - Funding Information:
This work was supported in part by NIBIB ( R01EB018306 ), NIH , United States, and NINDS ( R01NS093416 ; U01NS103882 ), NIH, United States. We also like to thank Dr. Bindu Balakrishnan for acquiring the images in Fig. 5 .
Funding Information:
This work was supported in part by NIBIB (R01EB018306), NIH, United States, and NINDS (R01NS093416; U01NS103882), NIH, United States. We also like to thank Dr. Bindu Balakrishnan for acquiring the images in Fig. 5.
Publisher Copyright:
© 2019
PY - 2019/8
Y1 - 2019/8
N2 - Identifying and harnessing regenerative pathways while suppressing the growth-inhibiting processes of the biological response to injury is the central goal of stimulating neurogenesis after central nervous system (CNS) injury. However, due to the complexity of the mature CNS involving a plethora of cellular pathways and extracellular cues, as well as difficulties in accessibility without highly invasive procedures, clinical successes of regenerative medicine for CNS injuries have been extremely limited. Current interventions primarily focus on stabilization and mitigation of further neuronal death rather than direct stimulation of neurogenesis. In the past few decades, nanotechnology has offered substantial innovations to the field of regenerative medicine. Their nanoscale features allow for the fine tuning of biological interactions for enhancing drug delivery and stimulating cellular processes. This review gives an overview of nanotechnology applications in CNS regeneration organized according to cellular and extracellular targets and discuss future directions for the field.
AB - Identifying and harnessing regenerative pathways while suppressing the growth-inhibiting processes of the biological response to injury is the central goal of stimulating neurogenesis after central nervous system (CNS) injury. However, due to the complexity of the mature CNS involving a plethora of cellular pathways and extracellular cues, as well as difficulties in accessibility without highly invasive procedures, clinical successes of regenerative medicine for CNS injuries have been extremely limited. Current interventions primarily focus on stabilization and mitigation of further neuronal death rather than direct stimulation of neurogenesis. In the past few decades, nanotechnology has offered substantial innovations to the field of regenerative medicine. Their nanoscale features allow for the fine tuning of biological interactions for enhancing drug delivery and stimulating cellular processes. This review gives an overview of nanotechnology applications in CNS regeneration organized according to cellular and extracellular targets and discuss future directions for the field.
KW - Brain injury
KW - Extracellular matrix
KW - Nanotechnology
KW - Neurogenesis
KW - Regenerative medicine
KW - Targeted drug delivery
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U2 - 10.1016/j.addr.2019.04.004
DO - 10.1016/j.addr.2019.04.004
M3 - Review article
C2 - 31668648
AN - SCOPUS:85066043105
SN - 0169-409X
VL - 148
SP - 3
EP - 18
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -