Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey

Howard S. Ying, Karoline Fackelmann, Ahmed Messoudi, Xiao fang Tang, Jean A. Büttner-Ennever, Anja K.E. Horn

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Motoneurons of the oculomotor nucleus subserving multiply innervated muscle fibres (MIF) receive different afferent inputs from the motoneurons subserving singly innervated muscle fibres (SIF). We asked whether MIF and SIF motoneurons have different neurotransmitter signalling expression profiles. Adult rhesus monkey extraocular muscles were injected with the retrograde tracer cholera toxin. Sections were then stained for various neurotransmitter-signalling markers. MIF motoneurons showed less glutamate receptor 4 (GluR4) and N-methyl-d-aspartate receptor 1 (NMDAR1) immunoreactivity, but showed similar amounts of glutamic acid decarboxylase (GAD) immunoreactive afferent terminals, compared to SIF motoneurons. This difference in excitatory neurotransmitter receptor expression may explain selective oculomotor deficits and allow development of selective pharmacotherapy in the future.

Original languageEnglish (US)
Title of host publicationUsing Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever
PublisherElsevier
Pages13-16
Number of pages4
ISBN (Print)9780444531636
DOIs
StatePublished - 2008

Publication series

NameProgress in Brain Research
Volume171
ISSN (Print)0079-6123

Keywords

  • AMPA
  • C-group
  • GABA
  • S-group
  • non-NMDA
  • non-twitch muscle fibre
  • twitch muscle fibre

ASJC Scopus subject areas

  • Neuroscience(all)

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