Neuronal PDZ domains: A promising new molecular target for inhaled anesthetics?

Yuan Xiang Tao, Roger A. Johns

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite widespread use of volatile general anesthetics in millions of patients each year, the mechanisms by which they exert multiple effects on the behavior of central neurons are poorly understood. PDZ [postsynaptic density 95 (PSD-95), discs large (Dlg), and zonula occludens-1 (Z0-1)] domains are ubiquitous protein interaction modules that participate in neuronal signaling. Recent studies have indicated that clinically relevant concentrations of inhaled anesthetics dose-dependently and specifically inhibit the PDZ domain-mediated protein interactions among multiprotein signaling complexes. These inhibitory effects are immediate, potent, reversible, and occur at a hydrophobic peptide-binding groove on the surface of the PDZ domain. Thus, the PDZ domain might be a new molecular target for inhalational anesthetics.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalMolecular interventions
Volume4
Issue number4
DOIs
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Molecular Medicine

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